Prognostic Tool for Risk Stratifying Patients with Epilepsy to Improve Clinical Outcomes
Earlier and more accurate methods to diagnose and treat Status Epilepticus (SE) and New-Onset Refractory Status Epilepticus (NORSE).
Simulated Microgravity Approach for Enhanced Stem Cell Potency
Simple and convenient method for enhancing medically-relevant stem cell properties (expansion and potency).
Omnivore RNA Pyrophosphatase: The Key to Universal 5′-end Deprotection
A versatile enzyme capable of completely removing a wide variety of 5′ caps and oligophosphates from RNA.
CX3CR-1GFP transgenic mice (B6.129P2(Cg)-Cx3cr1tm1Litt/J; Jax stock number: 005582)
The CX3CR-1GFP knock-in/knock-out mice express EGFP in monocytes, dendritic cells, NK cells, and brain microglia under control of the endogenous Cx3cr1 locus. These mice may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies.
Platform for Locally Assembling Antibody Drug Conjugates (ADCs) With Enhanced Specificity
Next-generation ADC platforms with high specificity and reduced systemic toxicity
Enhancing Neuronal Resistance to Neurodegeneration
Novel therapeutic approach to reverse or prevent the progression of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
Mutant-Selective HER2 Antibodies for Treatment of Major Cancer Types
Selective, differentiated, and efficacious antibody-based treatment for mutant HER2-mediated cancers without HER2 overexpression.
Diagnostic Interview for Seizure Classification Outside of Video EEG Recording (DISCOVER) Form
DISCOVER is a structured interview designed to allow remote reviewers to identify seizure types and confirm diagnosis in patients already diagnosed with epilepsy.
Intraoperative Ultra Rapid Digital Droplet PCR to Guide Tumor Resection
Quick determination of the percentage of tumor cells and their molecular-genetic signature with a high sensitivity and specificity to guide surgical tumor resection.
A Biomarker for Cerebral Amyloid Angiopathy (CAA) and Amyloid Related Imaging Abnormality Risk
A biofluid biomarker to reliably diagnose Cerebral Amyloid Angiopathy (CAA) and predict the risk of Amyloid-Related Imaging Abnormalities (ARIA) in Alzheimer’s disease patients.
Natural & Semi-Synthetic Prodrugs as Selective Antibiotics Against Colibactin-Producing E. coli for Colorectal Cancer Prevention
Precise and preventive therapeutic strategy for patients with a high risk of developing colorectal cancer.
Bright and Photostable Cyanine Dye Tags for Research Applications
Protein tags with high affinity and selectivity for off-the-shelf commercially-available fluorescent dyes that enhance their spectral properties.
Optimized Retron Editors for Enhanced Genome Engineering in Mammalian Cells
Efficient and scalable method for complex genome editing in mammalian cells that are compatible with lentiviral delivery.
Colonic Irrigation Solution
An efficacious, convenient, and easily tolerated method for improving polyp detection during routine colonoscopy procedures.
All-Trans Retinoic Acid (ATRA) to Prevent and Treat Atrial Fibrillation
A safe and effective disease-modifying treatment to prevent and treat atrial fibrillation (AF).
Cysteine Depletion as a Treatment for Obesity and Associated Metabolic Disorders
A rapid, safe, and tunable method of weight loss and metabolic regulation in the context of obesity and associated metabolic disorder treatment.
Inherited Genomic Signature Testing for Improved Immune-Checkpoint Inhibition Cancer Therapies
A robust, non-invasive predictive biomarker for personalized selection of cancer treatment options involving immune-checkpoint inhibition (ICI) therapies.
Modulating Neuron and Oligodendrocyte Survival by Targeting Astrocyte-Secreted Neurotoxic Lipids and Lipoproteins
Small Molecule Inhibitors of Bacterial CSE for Treatment of Diverse Antibiotic-Resistant Infections
Innovative approache to combat antibiotic resistance and enhance the efficacy of existing antibiotics, particularly against biofilm-encased and persister bacteria
Sindbis Virus-Based Vectors for the Oncolytic Immunotherapy of Solid Tumors
Innovative, efficacious, and safe treatment for ovarian and other types of cancers.
Monoclonal Antibodies for Efficient Removal of Uremic Toxins in Chronic Kidney Disease Patients
Effective removal of pathological albumin-bound uremic toxins in Chronic Kidney Disease patients, which are not removed by standard hemodialysis.
Repurposing Farnesyl Transferase Inhibitors for the Treatment of Cerebral Malaria
First-in-class treatment of cerebral malaria by preventing the pathological loss of the blood-brain barrier.
Targeting mutant NT5C2 in Acute Lymphoblastic Leukemia (ALL)
Apoptosis Inhibitor 5 (API5)-based Therapeutic for the Treatment of Inflammatory Bowel Diseases
A novel disease-modifying treatment of inflammatory bowel diseases that doesn't compromise the patient immune system.
Ultra High-Fidelity Single Molecule Sequencing
High-fidelity DNA sequencing method detecting base substitutions at a single-molecule level, able to explore mutation origins in cancer and aging.
A Novel Predictive Classifier of Follicular Lymphoma Patients for Improved Treatment Strategy
Accurate predictive biomarker to guide risk-adapted frontline therapy for follicular lymphoma
Inhibition of the Calcium Channel ORAI1 as a Therapeutic Strategy for the Treatment of Oral Cancer and Associated Allodynia
A non-surgical method for effectively treating both oral cancer and related pain.
CARPOOL: A High Throughput Drug Screening Platform
High throughput screening platform without the need for complex instrumentation or expensive consumables and compatible dead cell removal approach.
S-allylcysteine for Use in the Prevention and Treatment of Plasma Cell Dyscrasias
A treatment strategy for prevention of progression of SMM/MGUS to MM without the serious side effects of painful peripheral neuropathy.
Selective KRAS(G12D)-Binding Monobodies for the Treatment of Cancer
A selective, efficacious and versatile treatment for KRAS(G12D)-driven cancers
SCRATCH-seq: Capturing Dynamic Genetic Changes in Lymphocytes
A platform that allows the combined profiling of chromatin accessibility, transcription analysis with parallel analysis of B and T lymphocytes antigen repertoire.
Selective NRAS-Binding Monobodies for the Treatment of Cancer
A selective and efficacious inhibitor of NRAS applicable to all NRAS-driven cancers.
Topical Inhibition of HIF-1a as a Novel Therapeutic Strategy for Inflammatory Skin Diseases
An effective, differentiated, and targeted therapeutic strategy for the treatment of inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa.
Catalysts to Efficiently Convert Lignin Biomass to Valuable and Sustainable Chemicals
A highly efficient, selective, and sustainable method for converting lignin biomass into valuable, small molecule chemicals.
Epitranscriptomic Modulation of Type I IFN Pathway to Treat Cancer and Autoimmune, Inflammatory, and Infectious Diseases
An innovative and targeted approache to treat cancer and autoimmune, inflammatory, and infectious diseases
miRNA-Mediated Transgene Expression System for Improved Gene Therapies and Research Reagent Applications
A highly specific and tailorable transgene expression systems compatible with conventional gene therapy platforms
Clinical Prognostic Models for Stage II Melanoma Using Tumor miRNA Signatures
Multivalent Assembled Proteins (MAPs): Therapeutics for Cancer and Infectious Diseases
Tailorable multivalent therapeutic for targeting difficult protein-protein interaction (PPI) interfaces in the context of cancer and infectious diseases
Aryl-Diazonium Analogues as Potent DNA Cleavage Agents for Treating Cancer and Bacterial Infections
Potent, specific, modular, cost-effective, and synthetically-accessible agents for cytotoxic DNA cleavage.
Transcription-Associated Cas9 Targeting in Eukaryotic Cells
A novel mechanism for conditional spatiotemporal control of Cas9 activity without modification of its core protein domains, gRNA components, or expression levels.
Chip-based Prognostic Tool for Improved Leukemia Treatment Outcomes
Accurate, inexpensive, and rapid predictive tool to assess patient responsiveness to immunotherapies, such as chimeric antigen receptor (CAR) T-cell therapy
Drug Targets for Overcoming Resistance to KRAS G12C Inhibitors (G12Cis) in Cancer
Innovative therapies to overcome resistance to KRAS G12C inhibitors (G12Cis) in KRAS-mutant cancers.
Novel Probiotic Compositions for Improving Metabolism and Immunity
Innovative probiotic formulation to prevent and treat metabolic and immune disorders
Novel Class of Anthelmintic Compounds and Proprietary Screening Method for Anthelmintic Discovery
Novel anthelmintics with differentiated mechanisms of actions and therapeutic efficacy across multiple developmental stages
Therapeutic Hyaluronic Acid and Peptide Composition for Regenerative Repair of Cartilage Injury
Innovative disease-modifying method to treat knee cartilage injuries and prevent development of post-traumatic osteoarthritis (PTOA)
Injectable Therapeutic Hydrogel for the Treatment of Post-Traumatic Osteoarthritis
Injectable, minimally invasive, and effective disease-modifying therapeutic for post-traumatic osteoarthritis (PTOA) prevention and treatment
Hydrophobically Interspaced, Charged Peptides for the Treatment and Prevention of Dementia
An Innovative and efficacious therapeutic strategy to prevent and/or treat AD and other dementias.
Anti-CD97 Antibody-Drug Conjugates for the Treatment of AML and GBM
Innovative, efficacious, and improved treatment option for Acute Myeloid Leukemia (AML) and Glioblastoma (GBM)
Biomarkers of Severe and Cerebral Malaria
Diagnostic and prognostic proteinaceous biomarker for severe and cerebral malaria
Salt-Inducible Kinase Activators to Treat Bone and Mineral Diseases
An innovative and efficacious oral treatment for bone and mineral diseases.
High-Throughput Design and Engineering of Mammalian Cells
A novel approach for designing, building, and delivering large DNA vectors (>100kb) for highly customizable expression of multiple gene products.
Ultrasonic Probe Device and System and Methods for Generating Ultrasonic Images
Device for the Treatment of Lower Extremity Deep Vein Thrombosis
Small Molecule Inhibitors of SPNS2 for the Treatment of Chronic Inflammatory Diseases
Screening Method and Gene Therapy Approach for Treating Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia (ARVC/D)
An innovative and efficacious treatment targeting the genetic drivers of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D).
Methods of Sensitizing Estrogen Receptor-Positive Breast Cancer to Endocrine Therapy
ASRS DSM-5
The Adult ADHD Self-Report Screener, symptoms checklist, and proprietary scoring rules (ASRS DSM-5) is a self-report questionnaire designed to assess Attention Deficit Hyperactivity Disorder (ADHD) symptoms in adults (18+).
Apolipoprotein B Peptide Mimics for Atherosclerosis Treatment
Innovative, efficacious and complementary non lipoprotein-lowering treatments for atherosclerosis.
Efficient and High-Throughput Tool to Engineer Aligned 3D Collagen Matrices for Tissue Culture
Targeting Endocytosis in Nociceptors as a Non-Opioid Treatment Strategy for Chronic Pain
IL-17 Receptor Modulator Screen
Treatment of Melanoma Brain Metastasis by Inhibition of Amyloid Precursor Protein Cleavage
Method of Treating Lung Cancer in Patients with LKB1 Genetically-Inactivated Tumors
Vectored ACE2 Receptor Decoy for Prevention and Treatment of Pan-Coronavirus Infections
Innovative, alternative, and complementary treatment option for pan-coronavirus infections
Nanobodies Targeting SARS-CoV-2 NSP9 for COVID Treatment
Saliva-Based Cytokine Score to Predict the Severity of Clinical Periodontal Inflammation
CD11c-DTR Transgenic Mice (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )
The CD11c-DTR/GFP transgenic line 57 has the CD11c promoter (Itgax) directing expression of a diphtheria toxin receptor - enhanced green fluorescent protein (DTR/GFP) fusion protein to dendritic cell populations. (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )
TET2 Conditional Knockout Transgenic Mice
Conditionally-inducible mouse model for studying hematopoietic stem cell self-renewal and myeloid transformation. (B6;129S-Tet2tm1.1Iaai/J; Jax stock number: 017573)
Human Immunodeficiency Virus 1 (HIV-1) NL4-3 ΔEnv Vpr Luciferase Reporter Vector (pNL4-3.Luc.R-E-)
The HIV-1 NL4-3 luciferase reporter vector contains defective nef, env, and vpr genes cloned into pUC19. This reporter vector is useful for studying the role of the Nef and Vpr proteins in HIV infections and pathogenesis.
iScore: A Novel Method for Improved Risk Stratification of AML Patients
Robust and innovative method for accurate classification of AML patients to enable personalized treatment approaches
Novel Targets for Cancer Therapy
Aft7ip and Setdb1 identified as novel anti-cancer therapeutic targets
Identification of Zinc Fingers and Their DNA Targets
Novel Method for Labeling Cells and Living Animals with Isotopically Label Gases
Tau Kinase Inhibitor for Preventing or Treating Glucocorticoid-Induced Osteoporosis
Novel Enzyme in CoQ10 Biosynthesis Pathway as a Novel Target to Treat Pancreatic Ductal Adenocarcinoma
Treatment for Alzheimer’s Disease by Inhibiting Formation of Platelet Micro-Clots
Osteoarthritis (OA) Biomarker Suitable as a Point-of-Care Diagnostic
Methods of Treating Cancers Having a Deregulated Metabolic Pathway
A Novel Small Molecule PABA Derivative C45-NA Enhances Anti-Tumor Activity
Therapeutic Targeting of KMT2D Mutant Lung Cancer Via RTK-RAS Signaling Inhibition
Novel, Non-Staining Filling for Minimally-Invasive Treatment of Dental Caries
A biocompatible material for minimal invasive dentistry (MID) treatment of dental caries that is non-staining
Targeting the SARS-CoV-2 Viral-Immune Interaction for COVID-19 Therapy
New and innovative therapeutic approaches for blocking SARS-CoV-2 engagement with immune cells
Viral Vector Expression of Gabrb1b for the Treatment of Perceptual Deficits
Innovative and targeted approaches to treat perceptual deficits associated with reduced GABA receptor-mediated inhibitory postsynaptic potentials.
Novel miRNA and Protein Therapeutic Targets to Reduce Atherosclerosis
Steroid Modulators of Treg Lymphocytes and Pro-Inflammatory T Helper Cells For Autoimmune Disease
Innovative methods to modulate host T regulatory (Treg) and Th17 cells in autoimmune disease treatment.
Targeting a Novel Metabolic Network for Pancreatic Ductal Adenocarcinoma (PDAC) Treatment
New and innovative therapeutic approaches for efficient PDAC treatment
Paper-Based, Multiplexed Lamp Diagnostic for Pathogen Detection
Easy-to-use, inexpensive, accurate, and customizable pathogen detection devices.
Engineered Progranulin: A Promising Therapeutic Approach for Autoimmune Diseases
New efficacious TNFα inhibitors for the treatment of Rheumatoid arthritis and other autoimmune diseases.
PHOTACS: Photo-Activatable PROTACS
Spatial and temporal control over protein target degradation in diseased tissue
Multivalent Steroid Conjugates for Treatment of Castration-Resistant Prostate Cancer (CRPC)
A new generation of therapeutics for treating patients with enzalutamide-resistant CRPC.
Netrin-1 and UNC5B as Novel Targets in Metabolic Liver Diseases: NAFLD & NASH
Innovative and effective therapies for treating Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic SteatoHepatitis (NASH)
KaryoCreate (Karyotype CRISPR Engineered Aneuploidy Technology)
Efficient and less laborious isogenic model system to study aneuploidy in cancer and congenital syndromes.
FGF23 Ligand Trap: New Biologic for Treating Kidney Diseases
Innovative and efficacious treatments for chronic kidney disease and phosphate-wasting diseases.
Chimeric FGF21: Treatment of NAFLD, NASH and Hepatic Steatosis
New and efficacious versions of fibroblast growth factor 21 (FGF21) for metabolic liver diseases
ASRS v1.1 18-Question Symptom Checklist
The Adult ADHD Self-Report Scale (ASRS v1.1) is an 18-item self-report questionnaire designed to assess Attention Deficit Hyperactivity Disorder (ADHD) symptoms in adults (18+).
Adhesive Bandage for Rapid Pathogen Immune Response Detection
Innovative, portable, and customizable diagnostic devices for detecting an individual’s anti-pathogen immune response.
Angiotensin-Converting Enzyme 2 (ACE2) Immunoadhesin Microbody
Improved therapeutic approaches for blocking SARS-CoV-2 entry into host cells
Nano Zeolite-Y: A Novel and Cost-Effective Antibacterial Composition
A novel and cost-effective inorganic antibacterial composition.
Novel Lumican-Binding Peptides Acting on the Toll-Like Receptor Pathway in Inflammation and Related Conditions
Novel peptides for treating conditions or diseases resulting from dysregulation in the immune system, such as septic shock, wound healing and autoimmune diseases.
Targeting RNA Viruses Using Inhibitors of METTL3
New and effective treatments for COVID-19 and other viral infections caused by RNA viruses.
PKP2cKO Transgenic Mouse Model
Conditionally-inducible mouse model for arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited type of heart disease that can cause sudden death.
Anti-CD99 Antibodies Cytotoxic to Leukemia
New anti-CD99 antibodies for the treatment of rare hematological malignancies
Oral Insulin Delivery Nanoparticles for Diabetes Treatment
An improved method for insulin delivery that is more convenient and non-invasive.
Photoactivatable Lipid Nanoparticles for Drug Delivery
Novel photoactivatable lipid nanoparticles for drug delivery that allow for light-triggered drug release at the disease site
TET2 Modulators for the Treatment of Cancer and Inflammatory Diseases
A series of small molecule modulators (agonists and antagonists) of TET2 for potential use as therapeutics for rare hematological diseases.
Small Molecule Antagonist of the RAGE-DIAPH1 Signaling Axis for Diabetic Kidney Disease (DKD) Treatment
A new small molecule antagonist of the RAGE-DIAPH1 signaling axis, an important therapeutic node for the treatment of diabetes complications
Novel Biomarkers for Detection and Treatment of Immune Deficiencies During Pregnancy
A non-invasive method of detecting immune abnormalities during pregnancy to identify women at risk of infection-induced preterm birth.
Smart Braces
Improved orthodontic bracket design allowing for more precise movement of target teeth without significantly effecting adjacent teeth.
Novel Wound Healing Hydrogels
Relatively cheap and easy-to-produce fibers help stabilize this novel class of wound healing hydrogel and increase efficacy.
Non-Antibiotic Treatment of Staphylococcal Infections
Using re-engineered genetic elements of bacteria as antibacterial drones to block bacterial genes involved in virulence/viability.
Endock: Docking Station for Medical Instruments
An improved method of organization of medical instruments during procedures such as endoscopies and colonoscopies.
Succinate Receptor 1 (SUCNR1) Antagonists to Treat Neuroinflammation
A promising therapeutic target for the prevention and/or treatment of neurodegenerative diseases.
Avobenzone-Dendrimer Conjugates
The use of a dendrimer scaffold to stabilize avobenzone in sunscreens and improve photochemical properties.
A Method for Treating Autoimmune Disease Exacerbated by Host Immune Response to Commensal Bacteria
Targeting disease-associated bacteria via small molecule or biologics approaches to reduce or eliminate the harmful species.
NSP14/10 Complex Inhibitors for the Treatment of SARS-CoV-2 and Pan-Coronavirus Infections
Innovative and efficacious therapeutic to treat current and future pan-coronavirus infections
Single-Domain Antibodies (sdAbs) Against Tau and A-syn as Therapeutic and Diagnostic Tools for Neurodegenerative Diseases
The unique structural and biological features of the sdAbs provide a highly effective way of treating Alzheimer’s and Parkinson’s diseases
Novel MicroRNA-30c Analogs to Reduce Secretion of Apolipoprotein B in Human Hepatoma Cells
Therapeutic agents for lowering plasma lipid levels without causing the steatosis associated to microsomal transfer protein inhibitors.
A Novel Blood Marker for Prognostication and Treatment of Non-Small Cell Lung Cancer
Transgenic Mouse Model Expressing C217G Uromodulin
Transgenic mouse model expressing a human uromodulin mutant mimicking hereditary human mutant uromodulin caused kidney diseases for testing diagnostics and therapy.