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Omnivore RNA Pyrophosphatase: The Key to Universal 5′-end Deprotection

A versatile enzyme capable of completely removing a wide variety of 5′ caps and oligophosphates from RNA.

CX3CR-1GFP transgenic mice (B6.129P2(Cg)-Cx3cr1tm1Litt/J; Jax stock number: 005582)

The CX3CR-1GFP knock-in/knock-out mice express EGFP in monocytes, dendritic cells, NK cells, and brain microglia under control of the endogenous Cx3cr1 locus. These mice may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies.

1 licensing option
Platform for Locally Assembling Antibody Drug Conjugates (ADCs) With Enhanced Specificity

Next-generation ADC platforms with high specificity and reduced systemic toxicity

Enhancing Neuronal Resistance to Neurodegeneration

Novel therapeutic approach to reverse or prevent the progression of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

Mutant-Selective HER2 Antibodies for Treatment of Major Cancer Types

Selective, differentiated, and efficacious antibody-based treatment for mutant HER2-mediated cancers without HER2 overexpression.

Diagnostic Interview for Seizure Classification Outside of Video EEG Recording (DISCOVER) Form

DISCOVER is a structured interview designed to allow remote reviewers to identify seizure types and confirm diagnosis in patients already diagnosed with epilepsy.

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Intraoperative Ultra Rapid Digital Droplet PCR to Guide Tumor Resection

Quick determination of the percentage of tumor cells and their molecular-genetic signature with a high sensitivity and specificity to guide surgical tumor resection.

A Biomarker for Cerebral Amyloid Angiopathy (CAA) and Amyloid Related Imaging Abnormality Risk

A biofluid biomarker to reliably diagnose Cerebral Amyloid Angiopathy (CAA) and predict the risk of Amyloid-Related Imaging Abnormalities (ARIA) in Alzheimer’s disease patients.

Natural & Semi-Synthetic Prodrugs as Selective Antibiotics Against Colibactin-Producing E. coli for Colorectal Cancer Prevention

Precise and preventive therapeutic strategy for patients with a high risk of developing colorectal cancer.

Bright and Photostable Cyanine Dye Tags for Research Applications

Protein tags with high affinity and selectivity for off-the-shelf commercially-available fluorescent dyes that enhance their spectral properties.

Optimized Retron Editors for Enhanced Genome Engineering in Mammalian Cells

Efficient and scalable method for complex genome editing in mammalian cells that are compatible with lentiviral delivery.

Colonic Irrigation Solution

An efficacious, convenient, and easily tolerated method for improving polyp detection during routine colonoscopy procedures.

All-Trans Retinoic Acid (ATRA) to Prevent and Treat Atrial Fibrillation

A safe and effective disease-modifying treatment to prevent and treat atrial fibrillation (AF).

Cysteine Depletion as a Treatment for Obesity and Associated Metabolic Disorders

A rapid, safe, and tunable method of weight loss and metabolic regulation in the context of obesity and associated metabolic disorder treatment.

Inherited Genomic Signature Testing for Improved Immune-Checkpoint Inhibition Cancer Therapies

A robust, non-invasive predictive biomarker for personalized selection of cancer treatment options involving immune-checkpoint inhibition (ICI) therapies.

Modulating Neuron and Oligodendrocyte Survival by Targeting Astrocyte-Secreted Neurotoxic Lipids and Lipoproteins

Small Molecule Inhibitors of Bacterial CSE for Treatment of Diverse Antibiotic-Resistant Infections

Innovative approache to combat antibiotic resistance and enhance the efficacy of existing antibiotics, particularly against biofilm-encased and persister bacteria

Sindbis Virus-Based Vectors for the Oncolytic Immunotherapy of Solid Tumors

Innovative, efficacious, and safe treatment for ovarian and other types of cancers.

Monoclonal Antibodies for Efficient Removal of Uremic Toxins in Chronic Kidney Disease Patients

Effective removal of pathological albumin-bound uremic toxins in Chronic Kidney Disease patients, which are not removed by standard hemodialysis.

Repurposing Farnesyl Transferase Inhibitors for the Treatment of Cerebral Malaria

First-in-class treatment of cerebral malaria by preventing the pathological loss of the blood-brain barrier.

Targeting mutant NT5C2 in Acute Lymphoblastic Leukemia (ALL)

Apoptosis Inhibitor 5 (API5)-based Therapeutic for the Treatment of Inflammatory Bowel Diseases

A novel disease-modifying treatment of inflammatory bowel diseases that doesn't compromise the patient immune system.

Ultra High-Fidelity Single Molecule Sequencing

High-fidelity DNA sequencing method detecting base substitutions at a single-molecule level, able to explore mutation origins in cancer and aging.

A Novel Predictive Classifier of Follicular Lymphoma Patients for Improved Treatment Strategy

Accurate predictive biomarker to guide risk-adapted frontline therapy for follicular lymphoma

Inhibition of the Calcium Channel ORAI1 as a Therapeutic Strategy for the Treatment of Oral Cancer and Associated Allodynia

A non-surgical method for effectively treating both oral cancer and related pain.

CARPOOL: A High Throughput Drug Screening Platform

High throughput screening platform without the need for complex instrumentation or expensive consumables and compatible dead cell removal approach.

S-allylcysteine for Use in the Prevention and Treatment of Plasma Cell Dyscrasias

A treatment strategy for prevention of progression of SMM/MGUS to MM without the serious side effects of painful peripheral neuropathy.

Selective KRAS(G12D)-Binding Monobodies for the Treatment of Cancer

A selective, efficacious and versatile treatment for KRAS(G12D)-driven cancers

SCRATCH-seq: Capturing Dynamic Genetic Changes in Lymphocytes

A platform that allows the combined profiling of chromatin accessibility, transcription analysis with parallel analysis of B and T lymphocytes antigen repertoire.

Selective NRAS-Binding Monobodies for the Treatment of Cancer

A selective and efficacious inhibitor of NRAS applicable to all NRAS-driven cancers.

Topical Inhibition of HIF-1a as a Novel Therapeutic Strategy for Inflammatory Skin Diseases

An effective, differentiated, and targeted therapeutic strategy for the treatment of inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa.

Catalysts to Efficiently Convert Lignin Biomass to Valuable and Sustainable Chemicals

A highly efficient, selective, and sustainable method for converting lignin biomass into valuable, small molecule chemicals.

Epitranscriptomic Modulation of Type I IFN Pathway to Treat Cancer and Autoimmune, Inflammatory, and Infectious Diseases

An innovative and targeted approache to treat cancer and autoimmune, inflammatory, and infectious diseases

miRNA-Mediated Transgene Expression System for Improved Gene Therapies and Research Reagent Applications

A highly specific and tailorable transgene expression systems compatible with conventional gene therapy platforms

Clinical Prognostic Models for Stage II Melanoma Using Tumor miRNA Signatures

Multivalent Assembled Proteins (MAPs): Therapeutics for Cancer and Infectious Diseases

Tailorable multivalent therapeutic for targeting difficult protein-protein interaction (PPI) interfaces in the context of cancer and infectious diseases

Aryl-Diazonium Analogues as Potent DNA Cleavage Agents for Treating Cancer and Bacterial Infections

Potent, specific, modular, cost-effective, and synthetically-accessible agents for cytotoxic DNA cleavage.

Transcription-Associated Cas9 Targeting in Eukaryotic Cells

A novel mechanism for conditional spatiotemporal control of Cas9 activity without modification of its core protein domains, gRNA components, or expression levels.

Chip-based Prognostic Tool for Improved Leukemia Treatment Outcomes

Accurate, inexpensive, and rapid predictive tool to assess patient responsiveness to immunotherapies, such as chimeric antigen receptor (CAR) T-cell therapy

Drug Targets for Overcoming Resistance to KRAS G12C Inhibitors (G12Cis) in Cancer

Innovative therapies to overcome resistance to KRAS G12C inhibitors (G12Cis) in KRAS-mutant cancers.

Novel Probiotic Compositions for Improving Metabolism and Immunity

Innovative probiotic formulation to prevent and treat metabolic and immune disorders

Novel Class of Anthelmintic Compounds and Proprietary Screening Method for Anthelmintic Discovery

Novel anthelmintics with differentiated mechanisms of actions and therapeutic efficacy across multiple developmental stages

Therapeutic Hyaluronic Acid and Peptide Composition for Regenerative Repair of Cartilage Injury

Innovative disease-modifying method to treat knee cartilage injuries and prevent development of post-traumatic osteoarthritis (PTOA)

Injectable Therapeutic Hydrogel for the Treatment of Post-Traumatic Osteoarthritis

Injectable, minimally invasive, and effective disease-modifying therapeutic for post-traumatic osteoarthritis (PTOA) prevention and treatment

Hydrophobically Interspaced, Charged Peptides for the Treatment and Prevention of Dementia

An Innovative and efficacious therapeutic strategy to prevent and/or treat AD and other dementias.

Anti-CD97 Antibody-Drug Conjugates for the Treatment of AML and GBM

Innovative, efficacious, and improved treatment option for Acute Myeloid Leukemia (AML) and Glioblastoma (GBM)

Biomarkers of Severe and Cerebral Malaria

Diagnostic and prognostic proteinaceous biomarker for severe and cerebral malaria

Salt-Inducible Kinase Activators to Treat Bone and Mineral Diseases

An innovative and efficacious oral treatment for bone and mineral diseases.

High-Throughput Design and Engineering of Mammalian Cells

A novel approach for designing, building, and delivering large DNA vectors (>100kb) for highly customizable expression of multiple gene products.

Ultrasonic Probe Device and System and Methods for Generating Ultrasonic Images

Device for the Treatment of Lower Extremity Deep Vein Thrombosis

Small Molecule Inhibitors of SPNS2 for the Treatment of Chronic Inflammatory Diseases

Screening Method and Gene Therapy Approach for Treating Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia (ARVC/D)

An innovative and efficacious treatment targeting the genetic drivers of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D).

Methods of Sensitizing Estrogen Receptor-Positive Breast Cancer to Endocrine Therapy

ASRS DSM-5

The Adult ADHD Self-Report Screener, symptoms checklist, and proprietary scoring rules (ASRS DSM-5) is a self-report questionnaire designed to assess Attention Deficit Hyperactivity Disorder (ADHD) symptoms in adults (18+).

2 licensing options
Apolipoprotein B Peptide Mimics for Atherosclerosis Treatment

Innovative, efficacious and complementary non lipoprotein-lowering treatments for atherosclerosis.

Efficient and High-Throughput Tool to Engineer Aligned 3D Collagen Matrices for Tissue Culture

Targeting Endocytosis in Nociceptors as a Non-Opioid Treatment Strategy for Chronic Pain

IL-17 Receptor Modulator Screen

Treatment of Melanoma Brain Metastasis by Inhibition of Amyloid Precursor Protein Cleavage

Method of Treating Lung Cancer in Patients with LKB1 Genetically-Inactivated Tumors

Vectored ACE2 Receptor Decoy for Prevention and Treatment of Pan-Coronavirus Infections

Innovative, alternative, and complementary treatment option for pan-coronavirus infections

Nanobodies Targeting SARS-CoV-2 NSP9 for COVID Treatment

Saliva-Based Cytokine Score to Predict the Severity of Clinical Periodontal Inflammation

CD11c-DTR Transgenic Mice (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )

The CD11c-DTR/GFP transgenic line 57 has the CD11c promoter (Itgax) directing expression of a diphtheria toxin receptor - enhanced green fluorescent protein (DTR/GFP) fusion protein to dendritic cell populations. (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )

1 licensing option
TET2 Conditional Knockout Transgenic Mice

Conditionally-inducible mouse model for studying hematopoietic stem cell self-renewal and myeloid transformation. (B6;129S-Tet2tm1.1Iaai/J; Jax stock number: 017573)

1 licensing option
Human Immunodeficiency Virus 1 (HIV-1) NL4-3 ΔEnv Vpr Luciferase Reporter Vector (pNL4-3.Luc.R-E-)

The HIV-1 NL4-3 luciferase reporter vector contains defective nef, env, and vpr genes cloned into pUC19. This reporter vector is useful for studying the role of the Nef and Vpr proteins in HIV infections and pathogenesis.

1 licensing option
iScore: A Novel Method for Improved Risk Stratification of AML Patients

Robust and innovative method for accurate classification of AML patients to enable personalized treatment approaches

Novel Targets for Cancer Therapy

Aft7ip and Setdb1 identified as novel anti-cancer therapeutic targets

Identification of Zinc Fingers and Their DNA Targets

Novel Method for Labeling Cells and Living Animals with Isotopically Label Gases

Tau Kinase Inhibitor for Preventing or Treating Glucocorticoid-Induced Osteoporosis

Novel Enzyme in CoQ10 Biosynthesis Pathway as a Novel Target to Treat Pancreatic Ductal Adenocarcinoma

Treatment for Alzheimer’s Disease by Inhibiting Formation of Platelet Micro-Clots

Osteoarthritis (OA) Biomarker Suitable as a Point-of-Care Diagnostic

Methods of Treating Cancers Having a Deregulated Metabolic Pathway

A Novel Small Molecule PABA Derivative C45-NA Enhances Anti-Tumor Activity

Therapeutic Targeting of KMT2D Mutant Lung Cancer Via RTK-RAS Signaling Inhibition

Novel, Non-Staining Filling for Minimally-Invasive Treatment of Dental Caries

A biocompatible material for minimal invasive dentistry (MID) treatment of dental caries that is non-staining

Targeting the SARS-CoV-2 Viral-Immune Interaction for COVID-19 Therapy

New and innovative therapeutic approaches for blocking SARS-CoV-2 engagement with immune cells

Viral Vector Expression of Gabrb1b for the Treatment of Perceptual Deficits

Innovative and targeted approaches to treat perceptual deficits associated with reduced GABA receptor-mediated inhibitory postsynaptic potentials.

Novel miRNA and Protein Therapeutic Targets to Reduce Atherosclerosis

Steroid Modulators of Treg Lymphocytes and Pro-Inflammatory T Helper Cells For Autoimmune Disease

Innovative methods to modulate host T regulatory (Treg) and Th17 cells in autoimmune disease treatment.

Targeting a Novel Metabolic Network for Pancreatic Ductal Adenocarcinoma (PDAC) Treatment

New and innovative therapeutic approaches for efficient PDAC treatment

Paper-Based, Multiplexed Lamp Diagnostic for Pathogen Detection

Easy-to-use, inexpensive, accurate, and customizable pathogen detection devices.

Engineered Progranulin: A Promising Therapeutic Approach for Autoimmune Diseases

New efficacious TNFα inhibitors for the treatment of Rheumatoid arthritis and other autoimmune diseases.

PHOTACS: Photo-Activatable PROTACS

Spatial and temporal control over protein target degradation in diseased tissue

Multivalent Steroid Conjugates for Treatment of Castration-Resistant Prostate Cancer (CRPC)

A new generation of therapeutics for treating patients with enzalutamide-resistant CRPC.

Netrin-1 and UNC5B as Novel Targets in Metabolic Liver Diseases: NAFLD & NASH

Innovative and effective therapies for treating Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic SteatoHepatitis (NASH)

KaryoCreate (Karyotype CRISPR Engineered Aneuploidy Technology)

Efficient and less laborious isogenic model system to study aneuploidy in cancer and congenital syndromes.

FGF23 Ligand Trap: New Biologic for Treating Kidney Diseases

Innovative and efficacious treatments for chronic kidney disease and phosphate-wasting diseases.

Chimeric FGF21: Treatment of NAFLD, NASH and Hepatic Steatosis

New and efficacious versions of fibroblast growth factor 21 (FGF21) for metabolic liver diseases

ASRS v1.1 18-Question Symptom Checklist

The Adult ADHD Self-Report Scale (ASRS v1.1) is an 18-item self-report questionnaire designed to assess Attention Deficit Hyperactivity Disorder (ADHD) symptoms in adults (18+).

2 licensing options
Adhesive Bandage for Rapid Pathogen Immune Response Detection

Innovative, portable, and customizable diagnostic devices for detecting an individual’s anti-pathogen immune response.

Angiotensin-Converting Enzyme 2 (ACE2) Immunoadhesin Microbody

Improved therapeutic approaches for blocking SARS-CoV-2 entry into host cells

Nano Zeolite-Y: A Novel and Cost-Effective Antibacterial Composition

A novel and cost-effective inorganic antibacterial composition.

Novel Lumican-Binding Peptides Acting on the Toll-Like Receptor Pathway in Inflammation and Related Conditions

Novel peptides for treating conditions or diseases resulting from dysregulation in the immune system, such as septic shock, wound healing and autoimmune diseases.

Targeting RNA Viruses Using Inhibitors of METTL3

New and effective treatments for COVID-19 and other viral infections caused by RNA viruses.

PKP2cKO Transgenic Mouse Model

Conditionally-inducible mouse model for arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited type of heart disease that can cause sudden death.

1 licensing option
Anti-CD99 Antibodies Cytotoxic to Leukemia

New anti-CD99 antibodies for the treatment of rare hematological malignancies

Oral Insulin Delivery Nanoparticles for Diabetes Treatment

An improved method for insulin delivery that is more convenient and non-invasive.

Photoactivatable Lipid Nanoparticles for Drug Delivery

Novel photoactivatable lipid nanoparticles for drug delivery that allow for light-triggered drug release at the disease site

TET2 Modulators for the Treatment of Cancer and Inflammatory Diseases

A series of small molecule modulators (agonists and antagonists) of TET2 for potential use as therapeutics for rare hematological diseases.

Small Molecule Antagonist of the RAGE-DIAPH1 Signaling Axis for Diabetic Kidney Disease (DKD) Treatment

A new small molecule antagonist of the RAGE-DIAPH1 signaling axis, an important therapeutic node for the treatment of diabetes complications

Novel Biomarkers for Detection and Treatment of Immune Deficiencies During Pregnancy

A non-invasive method of detecting immune abnormalities during pregnancy to identify women at risk of infection-induced preterm birth.

Smart Braces

Improved orthodontic bracket design allowing for more precise movement of target teeth without significantly effecting adjacent teeth.

Novel Wound Healing Hydrogels

Relatively cheap and easy-to-produce fibers help stabilize this novel class of wound healing hydrogel and increase efficacy.

Non-Antibiotic Treatment of Staphylococcal Infections

Using re-engineered genetic elements of bacteria as antibacterial drones to block bacterial genes involved in virulence/viability.

Endock: Docking Station for Medical Instruments

An improved method of organization of medical instruments during procedures such as endoscopies and colonoscopies.

Succinate Receptor 1 (SUCNR1) Antagonists to Treat Neuroinflammation

A promising therapeutic target for the prevention and/or treatment of neurodegenerative diseases.

Avobenzone-Dendrimer Conjugates

The use of a dendrimer scaffold to stabilize avobenzone in sunscreens and improve photochemical properties.

A Method for Treating Autoimmune Disease Exacerbated by Host Immune Response to Commensal Bacteria

Targeting disease-associated bacteria via small molecule or biologics approaches to reduce or eliminate the harmful species.

NSP14/10 Complex Inhibitors for the Treatment of SARS-CoV-2 and Pan-Coronavirus Infections

Innovative and efficacious therapeutic to treat current and future pan-coronavirus infections

Single-Domain Antibodies (sdAbs) Against Tau and A-syn as Therapeutic and Diagnostic Tools for Neurodegenerative Diseases

The unique structural and biological features of the sdAbs provide a highly effective way of treating Alzheimer’s and Parkinson’s diseases

Novel MicroRNA-30c Analogs to Reduce Secretion of Apolipoprotein B in Human Hepatoma Cells

Therapeutic agents for lowering plasma lipid levels without causing the steatosis associated to microsomal transfer protein inhibitors.

A Novel Blood Marker for Prognostication and Treatment of Non-Small Cell Lung Cancer

Transgenic Mouse Model Expressing C217G Uromodulin

Transgenic mouse model expressing a human uromodulin mutant mimicking hereditary human mutant uromodulin caused kidney diseases for testing diagnostics and therapy.

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