CD11c-DTR Transgenic Mice (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )
The CD11c-DTR/GFP transgenic line 57 has the CD11c promoter (Itgax) directing expression of a diphtheria toxin receptor - enhanced green fluorescent protein (DTR/GFP) fusion protein to dendritic cell populations. (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )
Technology No. LIT01-08
Overview
Administration of diphtheria toxin results in depletion of dendritic cell populations. CD11c-DTR/GFP transgenic mice are useful in studies of mononuclear phagocyte origins and the specific role of dendritic cells in the immune response. Note: Shipping costs and logistics will be managed by JAX upon order approval.
In Goodwin et al. 2019 Genome Res. 29:494, it was discovered that line 57 has more than 20 copies of the CD11c-DTR/GFP transgene inserted into the 1700016L21Rik locus on chromosome 1 (80448681-80455738 bp [Build GRCm38/mm10]).
Note: Shipping costs and logistics will be managed by JAX upon order approval.
-
swap_vertical_circlemode_editAuthors (1)Dan Littman, PhD
-
swap_vertical_circlelibrary_booksReferences (1)
- Jung S, Unutmaz D, Wong P, et al. (2002), In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens, Immunity
-
swap_vertical_circlecloud_downloadSupporting documents (0)Additional files may be available once you've completed the transaction for this product. If you've already done so, please log into your account and visit My account / Downloads section to view them.