Platform for Locally Assembling Antibody Drug Conjugates (ADCs) With Enhanced Specificity
Next-generation ADC platforms with high specificity and reduced systemic toxicity
Mutant-Selective HER2 Antibodies for Treatment of Major Cancer Types
Selective, differentiated, and efficacious antibody-based treatment for mutant HER2-mediated cancers without HER2 overexpression.
Sindbis Virus-Based Vectors for the Oncolytic Immunotherapy of Solid Tumors
Innovative, efficacious, and safe treatment for ovarian and other types of cancers.
Inhibition of the Calcium Channel ORAI1 as a Therapeutic Strategy for the Treatment of Oral Cancer and Associated Allodynia
A non-surgical method for effectively treating both oral cancer and related pain.
S-allylcysteine for Use in the Prevention and Treatment of Plasma Cell Dyscrasias
A treatment strategy for prevention of progression of SMM/MGUS to MM without the serious side effects of painful peripheral neuropathy.
Epitranscriptomic Modulation of Type I IFN Pathway to Treat Cancer and Autoimmune, Inflammatory, and Infectious Diseases
An innovative and targeted approache to treat cancer and autoimmune, inflammatory, and infectious diseases
Clinical Prognostic Models for Stage II Melanoma Using Tumor miRNA Signatures
Multivalent Assembled Proteins (MAPs): Therapeutics for Cancer and Infectious Diseases
Tailorable multivalent therapeutic for targeting difficult protein-protein interaction (PPI) interfaces in the context of cancer and infectious diseases
Drug Targets for Overcoming Resistance to KRAS G12C Inhibitors (G12Cis) in Cancer
Innovative therapies to overcome resistance to KRAS G12C inhibitors (G12Cis) in KRAS-mutant cancers.
Anti-CD97 Antibody-Drug Conjugates for the Treatment of AML and GBM
Innovative, efficacious, and improved treatment option for Acute Myeloid Leukemia (AML) and Glioblastoma (GBM)
Methods of Sensitizing Estrogen Receptor-Positive Breast Cancer to Endocrine Therapy
Treatment of Melanoma Brain Metastasis by Inhibition of Amyloid Precursor Protein Cleavage
Method of Treating Lung Cancer in Patients with LKB1 Genetically-Inactivated Tumors
iScore: A Novel Method for Improved Risk Stratification of AML Patients
Robust and innovative method for accurate classification of AML patients to enable personalized treatment approaches
Novel Targets for Cancer Therapy
Aft7ip and Setdb1 identified as novel anti-cancer therapeutic targets
Therapeutic Targeting of KMT2D Mutant Lung Cancer Via RTK-RAS Signaling Inhibition
Targeting a Novel Metabolic Network for Pancreatic Ductal Adenocarcinoma (PDAC) Treatment
New and innovative therapeutic approaches for efficient PDAC treatment
Multivalent Steroid Conjugates for Treatment of Castration-Resistant Prostate Cancer (CRPC)
A new generation of therapeutics for treating patients with enzalutamide-resistant CRPC.
Anti-CD99 Antibodies Cytotoxic to Leukemia
New anti-CD99 antibodies for the treatment of rare hematological malignancies
TET2 Modulators for the Treatment of Cancer and Inflammatory Diseases
A series of small molecule modulators (agonists and antagonists) of TET2 for potential use as therapeutics for rare hematological diseases.