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Platform for Locally Assembling Antibody Drug Conjugates (ADCs) With Enhanced Specificity

Next-generation ADC platforms with high specificity and reduced systemic toxicity

Mutant-Selective HER2 Antibodies for Treatment of Major Cancer Types

Selective, differentiated, and efficacious antibody-based treatment for mutant HER2-mediated cancers without HER2 overexpression.

Sindbis Virus-Based Vectors for the Oncolytic Immunotherapy of Solid Tumors

Innovative, efficacious, and safe treatment for ovarian and other types of cancers.

Inhibition of the Calcium Channel ORAI1 as a Therapeutic Strategy for the Treatment of Oral Cancer and Associated Allodynia

A non-surgical method for effectively treating both oral cancer and related pain.

S-allylcysteine for Use in the Prevention and Treatment of Plasma Cell Dyscrasias

A treatment strategy for prevention of progression of SMM/MGUS to MM without the serious side effects of painful peripheral neuropathy.

Epitranscriptomic Modulation of Type I IFN Pathway to Treat Cancer and Autoimmune, Inflammatory, and Infectious Diseases

An innovative and targeted approache to treat cancer and autoimmune, inflammatory, and infectious diseases

Clinical Prognostic Models for Stage II Melanoma Using Tumor miRNA Signatures

Multivalent Assembled Proteins (MAPs): Therapeutics for Cancer and Infectious Diseases

Tailorable multivalent therapeutic for targeting difficult protein-protein interaction (PPI) interfaces in the context of cancer and infectious diseases

Drug Targets for Overcoming Resistance to KRAS G12C Inhibitors (G12Cis) in Cancer

Innovative therapies to overcome resistance to KRAS G12C inhibitors (G12Cis) in KRAS-mutant cancers.

Anti-CD97 Antibody-Drug Conjugates for the Treatment of AML and GBM

Innovative, efficacious, and improved treatment option for Acute Myeloid Leukemia (AML) and Glioblastoma (GBM)

Methods of Sensitizing Estrogen Receptor-Positive Breast Cancer to Endocrine Therapy

Treatment of Melanoma Brain Metastasis by Inhibition of Amyloid Precursor Protein Cleavage

Method of Treating Lung Cancer in Patients with LKB1 Genetically-Inactivated Tumors

iScore: A Novel Method for Improved Risk Stratification of AML Patients

Robust and innovative method for accurate classification of AML patients to enable personalized treatment approaches

Novel Targets for Cancer Therapy

Aft7ip and Setdb1 identified as novel anti-cancer therapeutic targets

Therapeutic Targeting of KMT2D Mutant Lung Cancer Via RTK-RAS Signaling Inhibition

Targeting a Novel Metabolic Network for Pancreatic Ductal Adenocarcinoma (PDAC) Treatment

New and innovative therapeutic approaches for efficient PDAC treatment

Multivalent Steroid Conjugates for Treatment of Castration-Resistant Prostate Cancer (CRPC)

A new generation of therapeutics for treating patients with enzalutamide-resistant CRPC.

Anti-CD99 Antibodies Cytotoxic to Leukemia

New anti-CD99 antibodies for the treatment of rare hematological malignancies

TET2 Modulators for the Treatment of Cancer and Inflammatory Diseases

A series of small molecule modulators (agonists and antagonists) of TET2 for potential use as therapeutics for rare hematological diseases.

A Novel Blood Marker for Prognostication and Treatment of Non-Small Cell Lung Cancer

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