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Murine Cell Line - Kras G12D/p53 -/-
Murine cell line Kras G12D/p53 -/- for studying Kras-driven cancers, such as non-small-cell lung cancer (NSCLC).
Murine Cell Line - Kras G12D, Lkb1 -/-, p53 -/-
Murine cell line Kras G12D/Lkb1 -/-, p53 -/- for studying Kras-driven cancers, such as non-small-cell lung cancer (NSCLC).
Murine Cell Line - Kras G12D/Lkb1 -/-
Murine cell line Kras G12D/Lkb1 -/- for studying Kras-driven cancers, such as non-small-cell lung cancer (NSCLC).
Addback clonal pair of Kras G12D/p53/Keap1 Murine Cell Line (HHMI/MIT)
This addback clonal pair of Kras G12D/+; p53 -/-, Keap1 -/- murine cell line can be used to study KEAP1 mutant tumor growth in cancers with NRF2 activation.
Kras G12D/p53/Keap1 Murine Cell Line (HHMI/MIT)
This Kras G12D/+; p53 -/-, Keap1 -/- murine cell line can be used to study KEAP1 mutant tumor growth in cancers with NRF2 activation.
Engineered murine fallopian tube epithial cell line that contains rp53 -/-; Brca1 -/-; MycOE
An engineered murine fallopian tube epithelial cell line with rp53 -/-; Brca1 -/-; MycOE mutations models high-grade serous tubo-ovarian carcinoma (HGSC) for studying tumor biology and testing new therapies
Engineered murine fallopian tube epithial cell line that contains rp53 -/-; Ccne1OE; MycOE
A novel murine cell line derived from fallopian tubes with specific genetic alterations mimics human CCNE1-driven high-grade serous tubo-ovarian cancer (HGSC), enabling in vivo and in vitro studies to explore tumor-immune interactions and test new therapies.
GHOST (3) CXCR4+CCR5+ cell line (NIH AIDS Reagent Program Catalog Number: 3942) (HHMI)
This cell line expresses CXCR4 and CCR5 on surface and also contains an HIV-2 LTR linked to a green fluorescent protein (GFP) gene. CD4, co-receptors and GFP are each under a different selection.
Mouse Leydig MA10 cell line deficient in SREPB2 (ATCC parent)
Mouse Leydig MA10 cell line deficient in sterol regulatory element-binding protein 2 (SREBP2) can be used to study cholestrol metabolism and steroidogenesis.
Mouse Leydig MA10 cell line deficient in MTTP (ATCC parent)
Mouse Leydig MA10 cell line deficient in microsomal triglyceride transfer protein (MTTP) can be used to study various aspects of lipid metabolism and steroidogenesis.
Apolipoprotein B deficient hepatoma cell line (VA)
ApoB CRISPR/Cas9 Knockout Huh7 Stable Cell Line
human hepatoma cell line deficient in microsomal triglyceride transfer protein (MTTP) (VA)
MTTP CRISPR/Cas9 Knockout Huh7 Stable Cell Line
SERPINB2 deficient cell lines for enhanced AdV manufacturing purposes
These cell lines lack SERPINB2 (Serine Protease Inhibitor) which yields increased titers during manufacturing processes. Infectious particle yield is a major bottleneck in the production of adenovirus as gene vectors in oncology and vaccines.
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr X (not cloned)
hCEC line with sgRNA to target chromosome X
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 13+21 (not cloned)
hCEC line with sgRNA 13-5 to target both chromosomes 13 and 21 in hCEC
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 18 (not cloned)
hCEC line with sgRNA targeting Chromosome 18
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 12 (not cloned)
hCEC line with sgRNA targeting Chromosome 12
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 9 (not cloned)
hCEC line with sgRNA targeting Chromosome 9
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 8 (not cloned)
hCEC line with sgRNA targeting Chromosome 8
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 6 (not cloned)
hCEC line with sgRNA targeting Chromosome 6
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 7 gain (x2)
Two isogenic hCeC clones for targeting chromosome 7 gain
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 18q loss (x2)
Two isogenic hCeC clones for targeting chromosome 18q loss
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-control Ctr sgNC (x2)
Two isogenic hCEC clones transduced with a lentiviral vector expressing the negative control sgRNA (sgNC) that does not target the human genome.
LS513 colorectal cancer (ATCC parent) - Chr 7-trisomic/7-disomic cell lines
Using KaryTap, the LS513 aneuploid colon cancer cell line carries 3 copies of chromosome 7.
LoVo Colorectal Cancer (ATCC parent) - Chr 5-trisomic/5-disomic cell lines
Using KaryTap, the LoVo aneuploid colon cancer cell line carries 3 copies of chr5p.
LoVo Colorectal Cancer (ATCC parent) - Chr 7-trisomic/7-disomic cell lines
Using KaryTap, the LoVo aneuploid colon cancer cell line carries 3 copies of chromosome 7.
Reh Cell line overexpressing NSD2 E1099K
The NSD2E1099K Over-Expressing Reh Stable Cell Line is a genetically modified human B-cell precursor leukemia (Reh) cell line engineered to stably overexpress the NSD2E1099K mutation. This mutation in the NSD2 (WHSC1/MMSET) gene is linked to chromatin remodeling and cancer progression, making this cell line a valuable tool for leukemia research.
UBA1 Knockout THP-1 Cell Line for the study of VEXAS (ATCC parent)
These parental THP-1 cell lines are control and doxycycline-induced conditional knock-outs of UBA1, with the additional reconstitution of either wild-type UBA1 or Met41Val UBA1