human hepatoma cell line deficient in microsomal triglyceride transfer protein (MTTP) (VA)

This Huh7 cell line features a stable knockout of microsomal triglyceride transfer protein (MTTP) using CRISPR/Cas9 genome editing. This modification allows for the study of MTTP (Microsomal Triglyceride Transfer Protein) function, which is crucial in the biosynthesis and secretion of very low-density lipoproteins (VLDL). Research applications include studying lipid metabolism disorders, liver function, and the development of treatments for conditions like abetalipoproteinemia.