Kras G12D/p53/Keap1 Murine Cell Line (HHMI/MIT)
This Kras G12D/+; p53 -/-, Keap1 -/- murine cell line can be used to study KEAP1 mutant tumor growth in cancers with NRF2 activation.
Technology No. PAP02-09
This is a mutant isogenic clonal cell line on a genetic background KrasG12D/+; p53-/-, Keap1 -/-. The addition of mKeap1 cDNA was achieved by cloning mouse Keap1 cDNA into Gibson compatible lentiviral backbone with hygromycin resistance cassette.