Natural & Semi-Synthetic Prodrugs as Selective Antibiotics Against Colibactin-Producing E. coli for Colorectal Cancer Prevention
Precise and preventive therapeutic strategy for patients with a high risk of developing colorectal cancer.
Bright and Photostable Cyanine Dye Tags for Research Applications
Protein tags with high affinity and selectivity for off-the-shelf commercially-available fluorescent dyes that enhance their spectral properties.
Small Molecule Inhibitors of Bacterial CSE for Treatment of Diverse Antibiotic-Resistant Infections
Innovative approache to combat antibiotic resistance and enhance the efficacy of existing antibiotics, particularly against biofilm-encased and persister bacteria
Catalysts to Efficiently Convert Lignin Biomass to Valuable and Sustainable Chemicals
A highly efficient, selective, and sustainable method for converting lignin biomass into valuable, small molecule chemicals.
Aryl-Diazonium Analogues as Potent DNA Cleavage Agents for Treating Cancer and Bacterial Infections
Potent, specific, modular, cost-effective, and synthetically-accessible agents for cytotoxic DNA cleavage.
Salt-Inducible Kinase Activators to Treat Bone and Mineral Diseases
An innovative and efficacious oral treatment for bone and mineral diseases.
Small Molecule Inhibitors of SPNS2 for the Treatment of Chronic Inflammatory Diseases
Identification of Zinc Fingers and Their DNA Targets
Novel Method for Labeling Cells and Living Animals with Isotopically Label Gases
Tau Kinase Inhibitor for Preventing or Treating Glucocorticoid-Induced Osteoporosis
Novel Enzyme in CoQ10 Biosynthesis Pathway as a Novel Target to Treat Pancreatic Ductal Adenocarcinoma
A Novel Small Molecule PABA Derivative C45-NA Enhances Anti-Tumor Activity
Targeting a Novel Metabolic Network for Pancreatic Ductal Adenocarcinoma (PDAC) Treatment
New and innovative therapeutic approaches for efficient PDAC treatment
Targeting RNA Viruses Using Inhibitors of METTL3
New and effective treatments for COVID-19 and other viral infections caused by RNA viruses.
Anti-CD99 Antibodies Cytotoxic to Leukemia
New anti-CD99 antibodies for the treatment of rare hematological malignancies
Photoactivatable Lipid Nanoparticles for Drug Delivery
Novel photoactivatable lipid nanoparticles for drug delivery that allow for light-triggered drug release at the disease site
TET2 Modulators for the Treatment of Cancer and Inflammatory Diseases
A series of small molecule modulators (agonists and antagonists) of TET2 for potential use as therapeutics for rare hematological diseases.
Small Molecule Antagonist of the RAGE-DIAPH1 Signaling Axis for Diabetic Kidney Disease (DKD) Treatment
A new small molecule antagonist of the RAGE-DIAPH1 signaling axis, an important therapeutic node for the treatment of diabetes complications
Succinate Receptor 1 (SUCNR1) Antagonists to Treat Neuroinflammation
A promising therapeutic target for the prevention and/or treatment of neurodegenerative diseases.
NSP14/10 Complex Inhibitors for the Treatment of SARS-CoV-2 and Pan-Coronavirus Infections
Innovative and efficacious therapeutic to treat current and future pan-coronavirus infections