Next-Generation Trachea-Esophageal Organoids for Scalable Disease Modeling
A scalable, reproducible, and human-specific platform for modeling trachea-esophageal development and congenital malformations such as Esophageal Atresia (EA)/ Tracheoesophageal Fistula (TEF).
KaryoCreate: Generating Chromosome-Specific Aneuploidies in Human Cells
Chromosome-specific aneuploidies on the cellular level.
Personalized Ex Vivo Platform for Testing Patient Responsiveness to Therapeutics for Inflammatory Disorders
A novel and innovative organoid co-culture system for studying immune-mediated tissue damage and testing patient responses to therapies for inflammatory disorders.
Rapid Generation of Single-Chain Antibodies for Use as Chimeric Antigen Receptors (CARs)
Rapid and efficient identification of high-affinity, antigen-specific single-chain antibodies for the construction of chimeric antigen receptors (CARs) to improve the effectiveness of CAR T-cell therapies, particularly in targeting challenging cancer antigens.
iCADD: Next-generation Screening Platform for Identifying Small Molecular Glue Degraders
An efficient, high-throughput platform to rapidly identify protein degraders targeting undruggable proteins for therapeutic development.
Innovative Clasping Antibody Platform for Producing High-Performance Antibodies to Challenging Targets
An innovative platform for generating antibodies with high affinity, high specificity, and low lot-to-lot variability against challenging target antigens.
In Silico, Machine Learning-Based Platform to Identify Disease-Causing Senescent Cells
Accurate and reproducible method to identify senescent cells for diagnostic and therapeutic applications.
Optimized Retron Editors for Enhanced Genome Engineering in Mammalian Cells
Efficient and scalable method for complex genome editing in mammalian cells that are compatible with lentiviral delivery.
Sindbis Virus-Based Vectors for the Oncolytic Immunotherapy of Solid Tumors
Innovative, efficacious, and safe treatment for ovarian and other types of cancers.
SCRATCH-seq: Capturing Dynamic Genetic Changes in Lymphocytes
A platform that allows the combined profiling of chromatin accessibility, transcription analysis with parallel analysis of B and T lymphocytes antigen repertoire.
miRNA-Mediated Transgene Expression System for Improved Gene Therapies and Research Reagent Applications
A highly specific and tailorable transgene expression systems compatible with conventional gene therapy platforms
Chip-based Prognostic Tool for Improved Leukemia Treatment Outcomes
Accurate, inexpensive, and rapid predictive tool to assess patient responsiveness to immunotherapies, such as chimeric antigen receptor (CAR) T-cell therapy
PHOTACS: Photo-Activatable PROTACS
Spatial and temporal control over protein target degradation in diseased tissue
Photoactivatable Lipid Nanoparticles for Drug Delivery
Novel photoactivatable lipid nanoparticles for drug delivery that allow for light-triggered drug release at the disease site