KaryoCreate: Generating Chromosome-Specific Aneuploidies in Human Cells
Chromosome-specific aneuploidies on the cellular level.
Targeting cooperative nutrient scavenging in cancer with pharmacological inhibition of CNPD2
An innovative strategy to prevent cancer growth in amino-acid deprived conditions by disrupting cooperative nutrient scavenging from extracellular peptides.
Rapid Generation of Single-Chain Antibodies for Use as Chimeric Antigen Receptors (CARs)
Rapid and efficient identification of high-affinity, antigen-specific single-chain antibodies for the construction of chimeric antigen receptors (CARs) to improve the effectiveness of CAR T-cell therapies, particularly in targeting challenging cancer antigens.
Intraoperative Ultra Rapid Digital Droplet PCR to Guide Tumor Resection
Quick determination of the percentage of tumor cells and their molecular-genetic signature with a high sensitivity and specificity to guide surgical tumor resection.
Natural & Semi-Synthetic Prodrugs as Selective Antibiotics Against Colibactin-Producing E. coli for Colorectal Cancer Prevention
Precise and preventive therapeutic strategy for patients with a high risk of developing colorectal cancer.
Targeting mutant NT5C2 in Acute Lymphoblastic Leukemia (ALL)
Selective KRAS(G12D)-Binding Monobodies for the Treatment of Cancer
A selective, efficacious and versatile treatment for KRAS(G12D)-driven cancers
SCRATCH-seq: Capturing Dynamic Genetic Changes in Lymphocytes
A platform that allows the combined profiling of chromatin accessibility, transcription analysis with parallel analysis of B and T lymphocytes antigen repertoire.
Selective NRAS-Binding Monobodies for the Treatment of Cancer
A selective and efficacious inhibitor of NRAS applicable to all NRAS-driven cancers.
Aryl-Diazonium Analogues as Potent DNA Cleavage Agents for Treating Cancer and Bacterial Infections
Potent, specific, modular, cost-effective, and synthetically-accessible agents for cytotoxic DNA cleavage.
Chip-based Prognostic Tool for Improved Leukemia Treatment Outcomes
Accurate, inexpensive, and rapid predictive tool to assess patient responsiveness to immunotherapies, such as chimeric antigen receptor (CAR) T-cell therapy
Multivalent Steroid Conjugates for Treatment of Castration-Resistant Prostate Cancer (CRPC)
A new generation of therapeutics for treating patients with enzalutamide-resistant CRPC.