Platform for Locally Assembling Antibody Drug Conjugates (ADCs) With Enhanced Specificity

Next-generation ADC platforms with high specificity and reduced systemic toxicity

Enhancing Neuronal Resistance to Neurodegeneration

Novel therapeutic approach to reverse or prevent the progression of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

Mutant-Selective HER2 Antibodies for Treatment of Major Cancer Types

Selective, differentiated, and efficacious antibody-based treatment for mutant HER2-mediated cancers without HER2 overexpression.

A Biomarker for Cerebral Amyloid Angiopathy (CAA) and Amyloid Related Imaging Abnormality Risk

A biofluid biomarker to reliably diagnose Cerebral Amyloid Angiopathy (CAA) and predict the risk of Amyloid-Related Imaging Abnormalities (ARIA) in Alzheimer’s disease patients.

Natural & Semi-Synthetic Prodrugs as Selective Antibiotics Against Colibactin-Producing E. coli for Colorectal Cancer Prevention

Precise and preventive therapeutic strategy for patients with a high risk of developing colorectal cancer.

All-Trans Retinoic Acid (ATRA) to Prevent and Treat Atrial Fibrillation

A safe and effective disease-modifying treatment to prevent and treat atrial fibrillation (AF).

Cysteine Depletion as a Treatment for Obesity and Associated Metabolic Disorders

A rapid, safe, and tunable method of weight loss and metabolic regulation in the context of obesity and associated metabolic disorder treatment.

Modulating Neuron and Oligodendrocyte Survival by Targeting Astrocyte-Secreted Neurotoxic Lipids and Lipoproteins

Small Molecule Inhibitors of Bacterial CSE for Treatment of Diverse Antibiotic-Resistant Infections

Innovative approache to combat antibiotic resistance and enhance the efficacy of existing antibiotics, particularly against biofilm-encased and persister bacteria

Sindbis Virus-Based Vectors for the Oncolytic Immunotherapy of Solid Tumors

Innovative, efficacious, and safe treatment for ovarian and other types of cancers.

Monoclonal Antibodies for Efficient Removal of Uremic Toxins in Chronic Kidney Disease Patients

Effective removal of pathological albumin-bound uremic toxins in Chronic Kidney Disease patients, which are not removed by standard hemodialysis.

Repurposing Farnesyl Transferase Inhibitors for the Treatment of Cerebral Malaria

First-in-class treatment of cerebral malaria by preventing the pathological loss of the blood-brain barrier.

Apoptosis Inhibitor 5 (API5)-based Therapeutic for the Treatment of Inflammatory Bowel Diseases

A novel disease-modifying treatment of inflammatory bowel diseases that doesn't compromise the patient immune system.

Inhibition of the Calcium Channel ORAI1 as a Therapeutic Strategy for the Treatment of Oral Cancer and Associated Allodynia

A non-surgical method for effectively treating both oral cancer and related pain.

S-allylcysteine for Use in the Prevention and Treatment of Plasma Cell Dyscrasias

A treatment strategy for prevention of progression of SMM/MGUS to MM without the serious side effects of painful peripheral neuropathy.

Topical Inhibition of HIF-1a as a Novel Therapeutic Strategy for Inflammatory Skin Diseases

An effective, differentiated, and targeted therapeutic strategy for the treatment of inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa.

Epitranscriptomic Modulation of Type I IFN Pathway to Treat Cancer and Autoimmune, Inflammatory, and Infectious Diseases

An innovative and targeted approache to treat cancer and autoimmune, inflammatory, and infectious diseases

miRNA-Mediated Transgene Expression System for Improved Gene Therapies and Research Reagent Applications

A highly specific and tailorable transgene expression systems compatible with conventional gene therapy platforms

Clinical Prognostic Models for Stage II Melanoma Using Tumor miRNA Signatures

Multivalent Assembled Proteins (MAPs): Therapeutics for Cancer and Infectious Diseases

Tailorable multivalent therapeutic for targeting difficult protein-protein interaction (PPI) interfaces in the context of cancer and infectious diseases

Aryl-Diazonium Analogues as Potent DNA Cleavage Agents for Treating Cancer and Bacterial Infections

Potent, specific, modular, cost-effective, and synthetically-accessible agents for cytotoxic DNA cleavage.

Drug Targets for Overcoming Resistance to KRAS G12C Inhibitors (G12Cis) in Cancer

Innovative therapies to overcome resistance to KRAS G12C inhibitors (G12Cis) in KRAS-mutant cancers.

Novel Probiotic Compositions for Improving Metabolism and Immunity

Innovative probiotic formulation to prevent and treat metabolic and immune disorders

Novel Class of Anthelmintic Compounds and Proprietary Screening Method for Anthelmintic Discovery

Novel anthelmintics with differentiated mechanisms of actions and therapeutic efficacy across multiple developmental stages

Therapeutic Hyaluronic Acid and Peptide Composition for Regenerative Repair of Cartilage Injury

Innovative disease-modifying method to treat knee cartilage injuries and prevent development of post-traumatic osteoarthritis (PTOA)

Injectable Therapeutic Hydrogel for the Treatment of Post-Traumatic Osteoarthritis

Injectable, minimally invasive, and effective disease-modifying therapeutic for post-traumatic osteoarthritis (PTOA) prevention and treatment

Hydrophobically Interspaced, Charged Peptides for the Treatment and Prevention of Dementia

An Innovative and efficacious therapeutic strategy to prevent and/or treat AD and other dementias.

Anti-CD97 Antibody-Drug Conjugates for the Treatment of AML and GBM

Innovative, efficacious, and improved treatment option for Acute Myeloid Leukemia (AML) and Glioblastoma (GBM)

Salt-Inducible Kinase Activators to Treat Bone and Mineral Diseases

An innovative and efficacious oral treatment for bone and mineral diseases.

Small Molecule Inhibitors of SPNS2 for the Treatment of Chronic Inflammatory Diseases

Screening Method and Gene Therapy Approach for Treating Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia (ARVC/D)

An innovative and efficacious treatment targeting the genetic drivers of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D).

Methods of Sensitizing Estrogen Receptor-Positive Breast Cancer to Endocrine Therapy

Apolipoprotein B Peptide Mimics for Atherosclerosis Treatment

Innovative, efficacious and complementary non lipoprotein-lowering treatments for atherosclerosis.

Targeting Endocytosis in Nociceptors as a Non-Opioid Treatment Strategy for Chronic Pain

Treatment of Melanoma Brain Metastasis by Inhibition of Amyloid Precursor Protein Cleavage

Method of Treating Lung Cancer in Patients with LKB1 Genetically-Inactivated Tumors

Vectored ACE2 Receptor Decoy for Prevention and Treatment of Pan-Coronavirus Infections

Innovative, alternative, and complementary treatment option for pan-coronavirus infections

Nanobodies Targeting SARS-CoV-2 NSP9 for COVID Treatment

iScore: A Novel Method for Improved Risk Stratification of AML Patients

Robust and innovative method for accurate classification of AML patients to enable personalized treatment approaches

Novel Targets for Cancer Therapy

Aft7ip and Setdb1 identified as novel anti-cancer therapeutic targets

Treatment for Alzheimer’s Disease by Inhibiting Formation of Platelet Micro-Clots

Osteoarthritis (OA) Biomarker Suitable as a Point-of-Care Diagnostic

Therapeutic Targeting of KMT2D Mutant Lung Cancer Via RTK-RAS Signaling Inhibition

Novel, Non-Staining Filling for Minimally-Invasive Treatment of Dental Caries

A biocompatible material for minimal invasive dentistry (MID) treatment of dental caries that is non-staining

Targeting the SARS-CoV-2 Viral-Immune Interaction for COVID-19 Therapy

New and innovative therapeutic approaches for blocking SARS-CoV-2 engagement with immune cells

Viral Vector Expression of Gabrb1b for the Treatment of Perceptual Deficits

Innovative and targeted approaches to treat perceptual deficits associated with reduced GABA receptor-mediated inhibitory postsynaptic potentials.

Novel miRNA and Protein Therapeutic Targets to Reduce Atherosclerosis

Steroid Modulators of Treg Lymphocytes and Pro-Inflammatory T Helper Cells For Autoimmune Disease

Innovative methods to modulate host T regulatory (Treg) and Th17 cells in autoimmune disease treatment.

Targeting a Novel Metabolic Network for Pancreatic Ductal Adenocarcinoma (PDAC) Treatment

New and innovative therapeutic approaches for efficient PDAC treatment

Paper-Based, Multiplexed Lamp Diagnostic for Pathogen Detection

Easy-to-use, inexpensive, accurate, and customizable pathogen detection devices.

Engineered Progranulin: A Promising Therapeutic Approach for Autoimmune Diseases

New efficacious TNFα inhibitors for the treatment of Rheumatoid arthritis and other autoimmune diseases.

Multivalent Steroid Conjugates for Treatment of Castration-Resistant Prostate Cancer (CRPC)

A new generation of therapeutics for treating patients with enzalutamide-resistant CRPC.

Netrin-1 and UNC5B as Novel Targets in Metabolic Liver Diseases: NAFLD & NASH

Innovative and effective therapies for treating Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic SteatoHepatitis (NASH)

FGF23 Ligand Trap: New Biologic for Treating Kidney Diseases

Innovative and efficacious treatments for chronic kidney disease and phosphate-wasting diseases.

Chimeric FGF21: Treatment of NAFLD, NASH and Hepatic Steatosis

New and efficacious versions of fibroblast growth factor 21 (FGF21) for metabolic liver diseases

Angiotensin-Converting Enzyme 2 (ACE2) Immunoadhesin Microbody

Improved therapeutic approaches for blocking SARS-CoV-2 entry into host cells

Nano Zeolite-Y: A Novel and Cost-Effective Antibacterial Composition

A novel and cost-effective inorganic antibacterial composition.

Novel Lumican-Binding Peptides Acting on the Toll-Like Receptor Pathway in Inflammation and Related Conditions

Novel peptides for treating conditions or diseases resulting from dysregulation in the immune system, such as septic shock, wound healing and autoimmune diseases.

Targeting RNA Viruses Using Inhibitors of METTL3

New and effective treatments for COVID-19 and other viral infections caused by RNA viruses.

Anti-CD99 Antibodies Cytotoxic to Leukemia

New anti-CD99 antibodies for the treatment of rare hematological malignancies

TET2 Modulators for the Treatment of Cancer and Inflammatory Diseases

A series of small molecule modulators (agonists and antagonists) of TET2 for potential use as therapeutics for rare hematological diseases.

Small Molecule Antagonist of the RAGE-DIAPH1 Signaling Axis for Diabetic Kidney Disease (DKD) Treatment

A new small molecule antagonist of the RAGE-DIAPH1 signaling axis, an important therapeutic node for the treatment of diabetes complications

Novel Biomarkers for Detection and Treatment of Immune Deficiencies During Pregnancy

A non-invasive method of detecting immune abnormalities during pregnancy to identify women at risk of infection-induced preterm birth.

Non-Antibiotic Treatment of Staphylococcal Infections

Using re-engineered genetic elements of bacteria as antibacterial drones to block bacterial genes involved in virulence/viability.

Succinate Receptor 1 (SUCNR1) Antagonists to Treat Neuroinflammation

A promising therapeutic target for the prevention and/or treatment of neurodegenerative diseases.

A Method for Treating Autoimmune Disease Exacerbated by Host Immune Response to Commensal Bacteria

Targeting disease-associated bacteria via small molecule or biologics approaches to reduce or eliminate the harmful species.

NSP14/10 Complex Inhibitors for the Treatment of SARS-CoV-2 and Pan-Coronavirus Infections

Innovative and efficacious therapeutic to treat current and future pan-coronavirus infections

Novel MicroRNA-30c Analogs to Reduce Secretion of Apolipoprotein B in Human Hepatoma Cells

Therapeutic agents for lowering plasma lipid levels without causing the steatosis associated to microsomal transfer protein inhibitors.

A Novel Blood Marker for Prognostication and Treatment of Non-Small Cell Lung Cancer

Transgenic Mouse Model Expressing C217G Uromodulin

Transgenic mouse model expressing a human uromodulin mutant mimicking hereditary human mutant uromodulin caused kidney diseases for testing diagnostics and therapy.