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Murine Cell Line - Kras G12D/p53 -/-
Murine cell line Kras G12D/p53 -/- for studying Kras-driven cancers, such as non-small-cell lung cancer (NSCLC).
Murine Cell Line - Kras G12D, Lkb1 -/-, p53 -/-
Murine cell line Kras G12D/Lkb1 -/-, p53 -/- for studying Kras-driven cancers, such as non-small-cell lung cancer (NSCLC).
Murine Cell Line - Kras G12D/Lkb1 -/-
Murine cell line Kras G12D/Lkb1 -/- for studying Kras-driven cancers, such as non-small-cell lung cancer (NSCLC).
FINO2 Compound for Ferroptosis
FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron.
Anti-human/mouse PrP antibody (TW1 clone) hybridoma cells
This novel monoclonal anti-PrP antibody (TW1) has an epitope on PrP that is similar to that of 6D11. Hybridoma TW1 cells can generate antibodies that can be used in a mouse model of AD with tau pathology, by targeting the tau oligomer to PrPC interaction.
OT-II LAG-3-/- mouse
These mice can be used for investigating LAG-3 and developing therapeutics that target LAG-3 dimerization, which is implicated in a variety of conditions, such as cancer and autoimmune diseases.
OT-I LAG-3-/- mouse
These mice can be used for investigating LAG-3 and developing therapeutics that target LAG-3 dimerization, which is implicated in a variety of conditions, such as cancer and autoimmune diseases.
RAGE conditional knockout transgenic mice (Columbia)
RAGE conditional knockout transgenic mice are useful for studying the deletion of RAGE which is implicated in energy metabolism and obesity.
AGER Conditional Knockout Transgenic Mice (Columbia)
AGER conditional knockout transgenic mice are useful for studying the deletion of Ager, a gene encoding RAGE, that is implicated in energy metabolism and obesity.
Diaph1 conditional knockout transgenic mice (Columbia)
These conditional knockout transgenic mice are useful for studying Diaphanous-1 (DIAPH1) and its role in tissue ischemia since DIAPH1 regulates actin dynamics, signal transduction, and metabolic functions.
Addback clonal pair of Kras G12D/p53/Keap1 Murine Cell Line (HHMI/MIT)
This addback clonal pair of Kras G12D/+; p53 -/-, Keap1 -/- murine cell line can be used to study KEAP1 mutant tumor growth in cancers with NRF2 activation.
Kras G12D/p53/Keap1 Murine Cell Line (HHMI/MIT)
This Kras G12D/+; p53 -/-, Keap1 -/- murine cell line can be used to study KEAP1 mutant tumor growth in cancers with NRF2 activation.
Engineered murine fallopian tube epithial cell line that contains rp53 -/-; Brca1 -/-; MycOE
An engineered murine fallopian tube epithelial cell line with rp53 -/-; Brca1 -/-; MycOE mutations models high-grade serous tubo-ovarian carcinoma (HGSC) for studying tumor biology and testing new therapies
Engineered murine fallopian tube epithial cell line that contains rp53 -/-; Ccne1OE; MycOE
A novel murine cell line derived from fallopian tubes with specific genetic alterations mimics human CCNE1-driven high-grade serous tubo-ovarian cancer (HGSC), enabling in vivo and in vitro studies to explore tumor-immune interactions and test new therapies.
B6.Cg-Ptprca Cx3cr1tm1Litt/LittJ (Jax No. 008451) Transgenic mice
These CX3CR1-GFP knock-in/knock-out mice express EGFP under control of the endogenous Cx3cr1 locus and also harbor the CD45.1 (Ly5.1 or Ptprca) allele, which is atypical for the C57BL/6 congenic background and may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies with C57BL/6 (CD45.2: Ptprcb) mice.
GHOST (3) CXCR4+CCR5+ cell line (NIH AIDS Reagent Program Catalog Number: 3942) (HHMI)
This cell line expresses CXCR4 and CCR5 on surface and also contains an HIV-2 LTR linked to a green fluorescent protein (GFP) gene. CD4, co-receptors and GFP are each under a different selection.
Mouse IgG1 monoclonal antibodies directed to human ROR gamma (DNA binding domain) produced by clone 4F3-3C8-2B7 (HHMI)
This mAb can be used to study inflammation and immunology related to Retinoid-Related Orphan Receptor(ROR) γ T. The clone has been validated for use in WB, FC & IF.
B6.129P2-Runx1tm1Tani/J transgenic mice (HHMI) (Jax No. 008772)
Exon 4 of these Runx1 (runt related transcription factor 1) targeted mutant mice is flanked by loxP sites. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene. When crossed to a CD4-cre mouse strain, progeny have fewer CD4+ T cells than wildtype mice and completely lack NK T cells.
C57BL/6-Tg(Tcra,Tcrb)2Litt/J transgenic mice (HHMI) (Jax. No. 027230)
T cells from these TCR transgenic mice recognize intestinal segmented filamentous bacteria (SFB) and predominantly become TH17 cells in SFB-colonized mice. These mice, derived from clone 7B8, are useful in studies of the relationship between commensal microbiota and organ-specific autoimmunity.
DC-SIGN transgenic mice (HHMI)
These transgenic mice expressing human DC-SIGN show reduced tissue damage and prolonged survival during mycobacterial infection, suggesting a protective role for DC-SIGN in limiting tuberculosis-induced pathology.
B6.FVB-Tg(Rorc-cre)1Litt/J transgenic mice (Jax. No 022791) (HHMI)
These transgenic mice express cre recombinase under the control of the mouse Rorc (RAR-related orphan receptor gamma; also called RORγt) promoter. Expression can be found in double positive thymocytes and their CD4+ and CD8+ single positive progeny as well as all αβ T cells of the spleen and lymphoid tissue inducer cells (LTi) and RORG+ innate lymphoid cells.
C57BL/6-Tg(Cd8a-cre)1ltan/J transgenic mice (Jax No. 008766) (HHMI)
These Cd8a-Cre transgenic mice have Cre recombinase activity observed in peripheral CD8+ T cells (CD8α+CD8β+ αβT cells and CD8α+CD8β- αβT cells, but not in CD4+CD8α-CD8β- αβT cells). The transgenic construct also contains GFP, which co-expresses with Cre, but the GFP expression is very low via flow cytometry. These mice may be useful for deletion of loxP-flanked sequences in CD8a-expressing cells.
Humanized mouse line expressing the human WT or CX3CR1I249/ M280 polymorphic variant (HHMI/USTA)
This mouse model expresses the human version of the receptor CX3CR1 harboring the sequence I249/M280 and can be used to study neuroinflammatory processes related to microglia-neuron communication in neurodegenerative diseases.
C.129P2-Cxcr6tm1Litt/J transgenic mice (HHMI) (Jax No. 005700)
In these Cxcr6 knock-out/reporter mice EGFP expression is restricted to spleen and lymph nodes. They are suitable for use in applications related to studies of hepatitis and various immune responses.
B6.129P2-Cxcr4tm2Yzo/J transgenic mice (HHMI) (Jax No. 008767)
These mice possess loxP sites on either side of exon 2 of the Cxcr4, chemokine (C-X-C motif) receptor 4 gene. When crossed with a cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene.
Pla2g12b floxed mice
These Pla2g12b floxed mice can be used to study cardiovascular disease.
ApoC3 KO mice
These ApoC3 KO mice can be used to study the role of APoC3 in lipid metabolism.
Leydig-cell specific MTP deficient mice
These Leydig-specific MTP-deficient mice can be used to study the role of microsomal triglyceride transfer protein (MTTP) in the testes, and sex hormone production.
Placenta-specific MTP deficient mice
These placenta-specific MTP-deficient mice can be used to study the role of microsomal triglyceride transfer protein (MTTP) in the placenta, which is crucial for embryonic development.
Zfp961 floxed mice
Zfp961 floxed mice enable the study of transcription factor Zfp961's role in modulating plasma lipoproteins and its impact on atherosclerosis.
Casz1 floxed mice
Casz1 floxed mice enable the study of transcription factor Casz1's role in modulating plasma lipoproteins and its impact on atherosclerosis.
Mouse Leydig MA10 cell line deficient in SREPB2 (ATCC parent)
Mouse Leydig MA10 cell line deficient in sterol regulatory element-binding protein 2 (SREBP2) can be used to study cholestrol metabolism and steroidogenesis.
Mouse Leydig MA10 cell line deficient in MTTP (ATCC parent)
Mouse Leydig MA10 cell line deficient in microsomal triglyceride transfer protein (MTTP) can be used to study various aspects of lipid metabolism and steroidogenesis.
Apolipoprotein B deficient hepatoma cell line (VA)
ApoB CRISPR/Cas9 Knockout Huh7 Stable Cell Line
human hepatoma cell line deficient in microsomal triglyceride transfer protein (MTTP) (VA)
MTTP CRISPR/Cas9 Knockout Huh7 Stable Cell Line
SERPINB2 deficient cell lines for enhanced AdV manufacturing purposes
These cell lines lack SERPINB2 (Serine Protease Inhibitor) which yields increased titers during manufacturing processes. Infectious particle yield is a major bottleneck in the production of adenovirus as gene vectors in oncology and vaccines.
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr X (not cloned)
hCEC line with sgRNA to target chromosome X
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 13+21 (not cloned)
hCEC line with sgRNA 13-5 to target both chromosomes 13 and 21 in hCEC
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 18 (not cloned)
hCEC line with sgRNA targeting Chromosome 18
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 12 (not cloned)
hCEC line with sgRNA targeting Chromosome 12
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 9 (not cloned)
hCEC line with sgRNA targeting Chromosome 9
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 8 (not cloned)
hCEC line with sgRNA targeting Chromosome 8
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 6 (not cloned)
hCEC line with sgRNA targeting Chromosome 6
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 7 gain (x2)
Two isogenic hCeC clones for targeting chromosome 7 gain
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-Chr 18q loss (x2)
Two isogenic hCeC clones for targeting chromosome 18q loss
Human Colonic Epithelial Cell (hCEC) Line (UTSW)-control Ctr sgNC (x2)
Two isogenic hCEC clones transduced with a lentiviral vector expressing the negative control sgRNA (sgNC) that does not target the human genome.
LS513 colorectal cancer (ATCC parent) - Chr 7-trisomic/7-disomic cell lines
Using KaryTap, the LS513 aneuploid colon cancer cell line carries 3 copies of chromosome 7.
LoVo Colorectal Cancer (ATCC parent) - Chr 5-trisomic/5-disomic cell lines
Using KaryTap, the LoVo aneuploid colon cancer cell line carries 3 copies of chr5p.
LoVo Colorectal Cancer (ATCC parent) - Chr 7-trisomic/7-disomic cell lines
Using KaryTap, the LoVo aneuploid colon cancer cell line carries 3 copies of chromosome 7.
Reh Cell line overexpressing NSD2 E1099K
The NSD2E1099K Over-Expressing Reh Stable Cell Line is a genetically modified human B-cell precursor leukemia (Reh) cell line engineered to stably overexpress the NSD2E1099K mutation. This mutation in the NSD2 (WHSC1/MMSET) gene is linked to chromatin remodeling and cancer progression, making this cell line a valuable tool for leukemia research.
UBA1 Knockout THP-1 Cell Line for the study of VEXAS (ATCC parent)
These parental THP-1 cell lines are control and doxycycline-induced conditional knock-outs of UBA1, with the additional reconstitution of either wild-type UBA1 or Met41Val UBA1
Axsl1 fl/fl:Tet2 fl/fl Conditional Knockout Mice
These conditional knockout mice are useful for studying and characterizing the role of Axsl1 and Tet2 in myeloid malignancies, such as myelodysplastic syndromes (MDSs).
Susd6 fl/fl Conditional Knockout Mice
These conditional knockout mice are useful for studying and characterizing the role of Susd6 in Acute Myeloid Leukemia (AML) and multiple solid tumor cancers.
Clpb fl/fl Conditional Knockout Mice
These conditional knockout mice are useful for studying and characterizing the role of Clpb in mitochondrial dysfunction in diseases such as Acute Myeloid Leukemia (AML).
C57BL/6 (Rosa-rtTA shTet3)
These reversible RNAi transgenic mice can be used to model knockdown and restoration of endogeous Tet3 in hematopoietic cells for TET3 mutant diseases.
C57BL/6 (Rosa-rtTA shTet2)
These reversible RNAi transgenic mice can be used to model knockdown and restoration of endogeous Tet2 in hematopoietic cells for TET2 mutant diseases.
C57BL/6 (Rosa-rtTA shTet1)
These reversible RNAi transgenic mice can be used to model knockdown and restoration of endogeous Tet1 in hematopoietic cells for TET1 mutant diseases.
Conditional AsxL1 Knock-out Mouse Model (Jax No. 025665)
These floxed mutant mice possess loxP sites flanking exons 5 through 10 of the Asxl1 gene and may be useful for generating conditional mutations in applications related to embryonic development, myelodysplastic syndromes and hematopoiesis.
CX3CR-1GFP transgenic mice (B6.129P2(Cg)-Cx3cr1tm1Litt/J; Jax stock number: 005582)
The CX3CR-1GFP knock-in/knock-out mice express EGFP in monocytes, dendritic cells, NK cells, and brain microglia under control of the endogenous Cx3cr1 locus. These mice may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies.
Optimized Retron Editors for Enhanced Genome Engineering in Mammalian Cells
Efficient and scalable method for complex genome editing in mammalian cells that are compatible with lentiviral delivery.
miRNA-Mediated Transgene Expression System for Improved Gene Therapies and Research Reagent Applications
A highly specific and tailorable transgene expression systems compatible with conventional gene therapy platforms
CD11c-DTR Transgenic Mice (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )
The CD11c-DTR/GFP transgenic line 57 has the CD11c promoter (Itgax) directing expression of a diphtheria toxin receptor - enhanced green fluorescent protein (DTR/GFP) fusion protein to dendritic cell populations. (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )
TET2 Conditional Knockout Transgenic Mice
Conditionally-inducible mouse model for studying hematopoietic stem cell self-renewal and myeloid transformation. (B6;129S-Tet2tm1.1Iaai/J; Jax stock number: 017573)
Human Immunodeficiency Virus 1 (HIV-1) NL4-3 ΔEnv Vpr Luciferase Reporter Vector (pNL4-3.Luc.R-E-)
The HIV-1 NL4-3 luciferase reporter vector contains defective nef, env, and vpr genes cloned into pUC19. This reporter vector is useful for studying the role of the Nef and Vpr proteins in HIV infections and pathogenesis.
Nano Zeolite-Y: A Novel and Cost-Effective Antibacterial Composition
A novel and cost-effective inorganic antibacterial composition.
PKP2cKO Transgenic Mouse Model
Conditionally-inducible mouse model for arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited type of heart disease that can cause sudden death.
Transgenic Mouse Model Expressing C217G Uromodulin
Transgenic mouse model expressing a human uromodulin mutant mimicking hereditary human mutant uromodulin caused kidney diseases for testing diagnostics and therapy.