OT-II LAG-3-/- mouse
These mice can be used for investigating LAG-3 and developing therapeutics that target LAG-3 dimerization, which is implicated in a variety of conditions, such as cancer and autoimmune diseases.
Technology No. WAN05-21
These global knockout mice can be used to study the role of LAG3 in cancer and autoimmune diseases. LAG-3−/− mice were immunized with mouse and human LAG-3 Fc fusion protein in complete Freund’s adjuvant and subsequently boosted twice with mouse and human LAG-3 Fc fusion protein in incomplete Freund’s adjuvant. Available in OT-I and OT-II T-cell receptor mice.