PKP2cKO Transgenic Mouse Model
Conditionally-inducible mouse model for arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited type of heart disease that can cause sudden death.
Technology No. DEL05-01
The PKP2cKO transgenic mouse, also denoted “PKP2-CreErt2 mice”, is a conditionally-inducible Plakophilin-2 (PKP2) knockout model for arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited type of heart disease that can cause sudden death. Conditional knockout of PKP2 is cardiomyocyte-specific and tamoxifen-activated. ARVC is also known as arrhythmogenic right ventricular dysplasia (ARVD) and arrhythmogenic cardiomyopathy (ACM).
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swap_vertical_circlemode_editAuthors (1)Mario Delmar, MD, PhD
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swap_vertical_circlelibrary_booksReferences (1)
- Cerrone M, Montnach J, Lin X, Zhao YT, Zhang M, Agullo-Pascual E, Leo-Macias A, Alvarado FJ, Dolgalev I, Karathanos TV, Malkani K, Van Opbergen CJM, van Bavel JJA, Yang HQ, Vasquez C, Tester D, Fowler S, Liang F, Rothenberg E, Heguy A, Morley GE, Coetzee WA, Trayanova NA, Ackerman MJ, van Veen TAB, Valdivia HH, Delmar M. , Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm
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