Mouse IgG1 monoclonal antibodies directed to human ROR gamma (DNA binding domain) produced by clone 4F3-3C8-2B7 (HHMI)
This mAb can be used to study inflammation and immunology related to Retinoid-Related Orphan Receptor(ROR) γ T. The clone has been validated for use in WB, FC & IF.
Technology No. LIT01-59
Retinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells. Biological source is hamster (Armenian).