Pla2g12b floxed mice

Mutations in Phospholipase A2 group 12B (PLA2G12B) are known to disrupt lipoprotein homeostasis. These mice are derived from incrosses of Pla2g12bhlb218/+ mice , or incrosses of their heterozygous progeny, which were maintained in the C57BL/6 J background. This allele was generated via ENU mutagenesis, and results in a missense substitution (C129Y). PLA2G12B mutant mice show profound resistance to atherosclerosis, suggesting an evolutionary tradeoff between triglyceride transport and cardiovascular disease risk.