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CX3CR-1GFP transgenic mice (B6.129P2(Cg)-Cx3cr1tm1Litt/J; Jax stock number: 005582)

The CX3CR-1GFP knock-in/knock-out mice express EGFP in monocytes, dendritic cells, NK cells, and brain microglia under control of the endogenous Cx3cr1 locus. These mice may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies.

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Platform for Locally Assembling Antibody Drug Conjugates (ADCs) With Enhanced Specificity

Next-generation ADC platforms with high specificity and reduced systemic toxicity

Natural & Semi-Synthetic Prodrugs as Selective Antibiotics Against Colibactin-Producing E. coli for Colorectal Cancer Prevention

Precise and preventive therapeutic strategy for patients with a high risk of developing colorectal cancer.

Bright and Photostable Cyanine Dye Tags for Research Applications

Protein tags with high affinity and selectivity for off-the-shelf commercially-available fluorescent dyes that enhance their spectral properties.

Colonic Irrigation Solution

An efficacious, convenient, and easily tolerated method for improving polyp detection during routine colonoscopy procedures.

All-Trans Retinoic Acid (ATRA) to Prevent and Treat Atrial Fibrillation

A safe and effective disease-modifying treatment to prevent and treat atrial fibrillation (AF).

Cysteine Depletion as a Treatment for Obesity and Associated Metabolic Disorders

A rapid, safe, and tunable method of weight loss and metabolic regulation in the context of obesity and associated metabolic disorder treatment.

Repurposing Farnesyl Transferase Inhibitors for the Treatment of Cerebral Malaria

First-in-class treatment of cerebral malaria by preventing the pathological loss of the blood-brain barrier.

Apoptosis Inhibitor 5 (API5)-based Therapeutic for the Treatment of Inflammatory Bowel Diseases

A novel disease-modifying treatment of inflammatory bowel diseases that doesn't compromise the patient immune system.

Selective KRAS(G12D)-Binding Monobodies for the Treatment of Cancer

A selective, efficacious and versatile treatment for KRAS(G12D)-driven cancers

Selective NRAS-Binding Monobodies for the Treatment of Cancer

A selective and efficacious inhibitor of NRAS applicable to all NRAS-driven cancers.

Catalysts to Efficiently Convert Lignin Biomass to Valuable and Sustainable Chemicals

A highly efficient, selective, and sustainable method for converting lignin biomass into valuable, small molecule chemicals.

miRNA-Mediated Transgene Expression System for Improved Gene Therapies and Research Reagent Applications

A highly specific and tailorable transgene expression systems compatible with conventional gene therapy platforms

Multivalent Assembled Proteins (MAPs): Therapeutics for Cancer and Infectious Diseases

Tailorable multivalent therapeutic for targeting difficult protein-protein interaction (PPI) interfaces in the context of cancer and infectious diseases

Aryl-Diazonium Analogues as Potent DNA Cleavage Agents for Treating Cancer and Bacterial Infections

Potent, specific, modular, cost-effective, and synthetically-accessible agents for cytotoxic DNA cleavage.

Chip-based Prognostic Tool for Improved Leukemia Treatment Outcomes

Accurate, inexpensive, and rapid predictive tool to assess patient responsiveness to immunotherapies, such as chimeric antigen receptor (CAR) T-cell therapy

Drug Targets for Overcoming Resistance to KRAS G12C Inhibitors (G12Cis) in Cancer

Innovative therapies to overcome resistance to KRAS G12C inhibitors (G12Cis) in KRAS-mutant cancers.

Novel Probiotic Compositions for Improving Metabolism and Immunity

Innovative probiotic formulation to prevent and treat metabolic and immune disorders

Novel Class of Anthelmintic Compounds and Proprietary Screening Method for Anthelmintic Discovery

Novel anthelmintics with differentiated mechanisms of actions and therapeutic efficacy across multiple developmental stages

Therapeutic Hyaluronic Acid and Peptide Composition for Regenerative Repair of Cartilage Injury

Innovative disease-modifying method to treat knee cartilage injuries and prevent development of post-traumatic osteoarthritis (PTOA)

Injectable Therapeutic Hydrogel for the Treatment of Post-Traumatic Osteoarthritis

Injectable, minimally invasive, and effective disease-modifying therapeutic for post-traumatic osteoarthritis (PTOA) prevention and treatment

Biomarkers of Severe and Cerebral Malaria

Diagnostic and prognostic proteinaceous biomarker for severe and cerebral malaria

Salt-Inducible Kinase Activators to Treat Bone and Mineral Diseases

An innovative and efficacious oral treatment for bone and mineral diseases.

Small Molecule Inhibitors of SPNS2 for the Treatment of Chronic Inflammatory Diseases

Screening Method and Gene Therapy Approach for Treating Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia (ARVC/D)

An innovative and efficacious treatment targeting the genetic drivers of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D).

Apolipoprotein B Peptide Mimics for Atherosclerosis Treatment

Innovative, efficacious and complementary non lipoprotein-lowering treatments for atherosclerosis.

Efficient and High-Throughput Tool to Engineer Aligned 3D Collagen Matrices for Tissue Culture

Targeting Endocytosis in Nociceptors as a Non-Opioid Treatment Strategy for Chronic Pain

IL-17 Receptor Modulator Screen

Vectored ACE2 Receptor Decoy for Prevention and Treatment of Pan-Coronavirus Infections

Innovative, alternative, and complementary treatment option for pan-coronavirus infections

Nanobodies Targeting SARS-CoV-2 NSP9 for COVID Treatment

Saliva-Based Cytokine Score to Predict the Severity of Clinical Periodontal Inflammation

CD11c-DTR Transgenic Mice (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )

The CD11c-DTR/GFP transgenic line 57 has the CD11c promoter (Itgax) directing expression of a diphtheria toxin receptor - enhanced green fluorescent protein (DTR/GFP) fusion protein to dendritic cell populations. (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )

1 licensing option
TET2 Conditional Knockout Transgenic Mice

Conditionally-inducible mouse model for studying hematopoietic stem cell self-renewal and myeloid transformation. (B6;129S-Tet2tm1.1Iaai/J; Jax stock number: 017573)

1 licensing option
iScore: A Novel Method for Improved Risk Stratification of AML Patients

Robust and innovative method for accurate classification of AML patients to enable personalized treatment approaches

Novel, Non-Staining Filling for Minimally-Invasive Treatment of Dental Caries

A biocompatible material for minimal invasive dentistry (MID) treatment of dental caries that is non-staining

Targeting the SARS-CoV-2 Viral-Immune Interaction for COVID-19 Therapy

New and innovative therapeutic approaches for blocking SARS-CoV-2 engagement with immune cells

Viral Vector Expression of Gabrb1b for the Treatment of Perceptual Deficits

Innovative and targeted approaches to treat perceptual deficits associated with reduced GABA receptor-mediated inhibitory postsynaptic potentials.

Steroid Modulators of Treg Lymphocytes and Pro-Inflammatory T Helper Cells For Autoimmune Disease

Innovative methods to modulate host T regulatory (Treg) and Th17 cells in autoimmune disease treatment.

Targeting a Novel Metabolic Network for Pancreatic Ductal Adenocarcinoma (PDAC) Treatment

New and innovative therapeutic approaches for efficient PDAC treatment

Paper-Based, Multiplexed Lamp Diagnostic for Pathogen Detection

Easy-to-use, inexpensive, accurate, and customizable pathogen detection devices.

Engineered Progranulin: A Promising Therapeutic Approach for Autoimmune Diseases

New efficacious TNFα inhibitors for the treatment of Rheumatoid arthritis and other autoimmune diseases.

PHOTACS: Photo-Activatable PROTACS

Spatial and temporal control over protein target degradation in diseased tissue

Multivalent Steroid Conjugates for Treatment of Castration-Resistant Prostate Cancer (CRPC)

A new generation of therapeutics for treating patients with enzalutamide-resistant CRPC.

Netrin-1 and UNC5B as Novel Targets in Metabolic Liver Diseases: NAFLD & NASH

Innovative and effective therapies for treating Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic SteatoHepatitis (NASH)

FGF23 Ligand Trap: New Biologic for Treating Kidney Diseases

Innovative and efficacious treatments for chronic kidney disease and phosphate-wasting diseases.

Chimeric FGF21: Treatment of NAFLD, NASH and Hepatic Steatosis

New and efficacious versions of fibroblast growth factor 21 (FGF21) for metabolic liver diseases

Adhesive Bandage for Rapid Pathogen Immune Response Detection

Innovative, portable, and customizable diagnostic devices for detecting an individual’s anti-pathogen immune response.

Angiotensin-Converting Enzyme 2 (ACE2) Immunoadhesin Microbody

Improved therapeutic approaches for blocking SARS-CoV-2 entry into host cells

Nano Zeolite-Y: A Novel and Cost-Effective Antibacterial Composition

A novel and cost-effective inorganic antibacterial composition.

ASOs Targeting CHROMR for the Treatment of Inflammatory Diseases

Innovative, efficacious, and patient-specific treatment for chronic inflammatory diseases mediated by hyperactive type-I interferon responses.

PKP2cKO Transgenic Mouse Model

Conditionally-inducible mouse model for arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited type of heart disease that can cause sudden death.

1 licensing option
Anti-CD99 Antibodies Cytotoxic to Leukemia

New anti-CD99 antibodies for the treatment of rare hematological malignancies

Oral Insulin Delivery Nanoparticles for Diabetes Treatment

An improved method for insulin delivery that is more convenient and non-invasive.

Photoactivatable Lipid Nanoparticles for Drug Delivery

Novel photoactivatable lipid nanoparticles for drug delivery that allow for light-triggered drug release at the disease site

TET2 Modulators for the Treatment of Cancer and Inflammatory Diseases

A series of small molecule modulators (agonists and antagonists) of TET2 for potential use as therapeutics for rare hematological diseases.

Small Molecule Antagonist of the RAGE-DIAPH1 Signaling Axis for Diabetic Kidney Disease (DKD) Treatment

A new small molecule antagonist of the RAGE-DIAPH1 signaling axis, an important therapeutic node for the treatment of diabetes complications

Succinate Receptor 1 (SUCNR1) Antagonists to Treat Neuroinflammation

A promising therapeutic target for the prevention and/or treatment of neurodegenerative diseases.

Avobenzone-Dendrimer Conjugates

The use of a dendrimer scaffold to stabilize avobenzone in sunscreens and improve photochemical properties.

NSP14/10 Complex Inhibitors for the Treatment of SARS-CoV-2 and Pan-Coronavirus Infections

Innovative and efficacious therapeutic to treat current and future pan-coronavirus infections

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