CX3CR-1GFP transgenic mice (B6.129P2(Cg)-Cx3cr1tm1Litt/J; Jax stock number: 005582)
The CX3CR-1GFP knock-in/knock-out mice express EGFP in monocytes, dendritic cells, NK cells, and brain microglia under control of the endogenous Cx3cr1 locus. These mice may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies.
Platform for Locally Assembling Antibody Drug Conjugates (ADCs) With Enhanced Specificity
Next-generation ADC platforms with high specificity and reduced systemic toxicity
Natural & Semi-Synthetic Prodrugs as Selective Antibiotics Against Colibactin-Producing E. coli for Colorectal Cancer Prevention
Precise and preventive therapeutic strategy for patients with a high risk of developing colorectal cancer.
Bright and Photostable Cyanine Dye Tags for Research Applications
Protein tags with high affinity and selectivity for off-the-shelf commercially-available fluorescent dyes that enhance their spectral properties.
Colonic Irrigation Solution
An efficacious, convenient, and easily tolerated method for improving polyp detection during routine colonoscopy procedures.
All-Trans Retinoic Acid (ATRA) to Prevent and Treat Atrial Fibrillation
A safe and effective disease-modifying treatment to prevent and treat atrial fibrillation (AF).
Cysteine Depletion as a Treatment for Obesity and Associated Metabolic Disorders
A rapid, safe, and tunable method of weight loss and metabolic regulation in the context of obesity and associated metabolic disorder treatment.
Repurposing Farnesyl Transferase Inhibitors for the Treatment of Cerebral Malaria
First-in-class treatment of cerebral malaria by preventing the pathological loss of the blood-brain barrier.
Apoptosis Inhibitor 5 (API5)-based Therapeutic for the Treatment of Inflammatory Bowel Diseases
A novel disease-modifying treatment of inflammatory bowel diseases that doesn't compromise the patient immune system.
Selective KRAS(G12D)-Binding Monobodies for the Treatment of Cancer
A selective, efficacious and versatile treatment for KRAS(G12D)-driven cancers
Selective NRAS-Binding Monobodies for the Treatment of Cancer
A selective and efficacious inhibitor of NRAS applicable to all NRAS-driven cancers.
Catalysts to Efficiently Convert Lignin Biomass to Valuable and Sustainable Chemicals
A highly efficient, selective, and sustainable method for converting lignin biomass into valuable, small molecule chemicals.
miRNA-Mediated Transgene Expression System for Improved Gene Therapies and Research Reagent Applications
A highly specific and tailorable transgene expression systems compatible with conventional gene therapy platforms
Multivalent Assembled Proteins (MAPs): Therapeutics for Cancer and Infectious Diseases
Tailorable multivalent therapeutic for targeting difficult protein-protein interaction (PPI) interfaces in the context of cancer and infectious diseases
Aryl-Diazonium Analogues as Potent DNA Cleavage Agents for Treating Cancer and Bacterial Infections
Potent, specific, modular, cost-effective, and synthetically-accessible agents for cytotoxic DNA cleavage.
Chip-based Prognostic Tool for Improved Leukemia Treatment Outcomes
Accurate, inexpensive, and rapid predictive tool to assess patient responsiveness to immunotherapies, such as chimeric antigen receptor (CAR) T-cell therapy
Drug Targets for Overcoming Resistance to KRAS G12C Inhibitors (G12Cis) in Cancer
Innovative therapies to overcome resistance to KRAS G12C inhibitors (G12Cis) in KRAS-mutant cancers.
Novel Probiotic Compositions for Improving Metabolism and Immunity
Innovative probiotic formulation to prevent and treat metabolic and immune disorders
Novel Class of Anthelmintic Compounds and Proprietary Screening Method for Anthelmintic Discovery
Novel anthelmintics with differentiated mechanisms of actions and therapeutic efficacy across multiple developmental stages
Therapeutic Hyaluronic Acid and Peptide Composition for Regenerative Repair of Cartilage Injury
Innovative disease-modifying method to treat knee cartilage injuries and prevent development of post-traumatic osteoarthritis (PTOA)
Injectable Therapeutic Hydrogel for the Treatment of Post-Traumatic Osteoarthritis
Injectable, minimally invasive, and effective disease-modifying therapeutic for post-traumatic osteoarthritis (PTOA) prevention and treatment
Biomarkers of Severe and Cerebral Malaria
Diagnostic and prognostic proteinaceous biomarker for severe and cerebral malaria
Salt-Inducible Kinase Activators to Treat Bone and Mineral Diseases
An innovative and efficacious oral treatment for bone and mineral diseases.
Small Molecule Inhibitors of SPNS2 for the Treatment of Chronic Inflammatory Diseases
Screening Method and Gene Therapy Approach for Treating Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia (ARVC/D)
An innovative and efficacious treatment targeting the genetic drivers of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D).
Apolipoprotein B Peptide Mimics for Atherosclerosis Treatment
Innovative, efficacious and complementary non lipoprotein-lowering treatments for atherosclerosis.
Efficient and High-Throughput Tool to Engineer Aligned 3D Collagen Matrices for Tissue Culture
Targeting Endocytosis in Nociceptors as a Non-Opioid Treatment Strategy for Chronic Pain
IL-17 Receptor Modulator Screen
Vectored ACE2 Receptor Decoy for Prevention and Treatment of Pan-Coronavirus Infections
Innovative, alternative, and complementary treatment option for pan-coronavirus infections
Nanobodies Targeting SARS-CoV-2 NSP9 for COVID Treatment
Saliva-Based Cytokine Score to Predict the Severity of Clinical Periodontal Inflammation
CD11c-DTR Transgenic Mice (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )
The CD11c-DTR/GFP transgenic line 57 has the CD11c promoter (Itgax) directing expression of a diphtheria toxin receptor - enhanced green fluorescent protein (DTR/GFP) fusion protein to dendritic cell populations. (B6.FVB-1700016L21RikTg [Itgax-DTR/EGFP] 57Lan/J; Jax stock number: 004509 )
TET2 Conditional Knockout Transgenic Mice
Conditionally-inducible mouse model for studying hematopoietic stem cell self-renewal and myeloid transformation. (B6;129S-Tet2tm1.1Iaai/J; Jax stock number: 017573)
iScore: A Novel Method for Improved Risk Stratification of AML Patients
Robust and innovative method for accurate classification of AML patients to enable personalized treatment approaches
Novel, Non-Staining Filling for Minimally-Invasive Treatment of Dental Caries
A biocompatible material for minimal invasive dentistry (MID) treatment of dental caries that is non-staining
Targeting the SARS-CoV-2 Viral-Immune Interaction for COVID-19 Therapy
New and innovative therapeutic approaches for blocking SARS-CoV-2 engagement with immune cells
Viral Vector Expression of Gabrb1b for the Treatment of Perceptual Deficits
Innovative and targeted approaches to treat perceptual deficits associated with reduced GABA receptor-mediated inhibitory postsynaptic potentials.
Steroid Modulators of Treg Lymphocytes and Pro-Inflammatory T Helper Cells For Autoimmune Disease
Innovative methods to modulate host T regulatory (Treg) and Th17 cells in autoimmune disease treatment.
Targeting a Novel Metabolic Network for Pancreatic Ductal Adenocarcinoma (PDAC) Treatment
New and innovative therapeutic approaches for efficient PDAC treatment
Paper-Based, Multiplexed Lamp Diagnostic for Pathogen Detection
Easy-to-use, inexpensive, accurate, and customizable pathogen detection devices.
Engineered Progranulin: A Promising Therapeutic Approach for Autoimmune Diseases
New efficacious TNFα inhibitors for the treatment of Rheumatoid arthritis and other autoimmune diseases.
PHOTACS: Photo-Activatable PROTACS
Spatial and temporal control over protein target degradation in diseased tissue
Multivalent Steroid Conjugates for Treatment of Castration-Resistant Prostate Cancer (CRPC)
A new generation of therapeutics for treating patients with enzalutamide-resistant CRPC.
Netrin-1 and UNC5B as Novel Targets in Metabolic Liver Diseases: NAFLD & NASH
Innovative and effective therapies for treating Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic SteatoHepatitis (NASH)
FGF23 Ligand Trap: New Biologic for Treating Kidney Diseases
Innovative and efficacious treatments for chronic kidney disease and phosphate-wasting diseases.
Chimeric FGF21: Treatment of NAFLD, NASH and Hepatic Steatosis
New and efficacious versions of fibroblast growth factor 21 (FGF21) for metabolic liver diseases
Adhesive Bandage for Rapid Pathogen Immune Response Detection
Innovative, portable, and customizable diagnostic devices for detecting an individual’s anti-pathogen immune response.
Angiotensin-Converting Enzyme 2 (ACE2) Immunoadhesin Microbody
Improved therapeutic approaches for blocking SARS-CoV-2 entry into host cells
Nano Zeolite-Y: A Novel and Cost-Effective Antibacterial Composition
A novel and cost-effective inorganic antibacterial composition.
ASOs Targeting CHROMR for the Treatment of Inflammatory Diseases
Innovative, efficacious, and patient-specific treatment for chronic inflammatory diseases mediated by hyperactive type-I interferon responses.
PKP2cKO Transgenic Mouse Model
Conditionally-inducible mouse model for arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited type of heart disease that can cause sudden death.
Anti-CD99 Antibodies Cytotoxic to Leukemia
New anti-CD99 antibodies for the treatment of rare hematological malignancies
Oral Insulin Delivery Nanoparticles for Diabetes Treatment
An improved method for insulin delivery that is more convenient and non-invasive.
Photoactivatable Lipid Nanoparticles for Drug Delivery
Novel photoactivatable lipid nanoparticles for drug delivery that allow for light-triggered drug release at the disease site
TET2 Modulators for the Treatment of Cancer and Inflammatory Diseases
A series of small molecule modulators (agonists and antagonists) of TET2 for potential use as therapeutics for rare hematological diseases.
Small Molecule Antagonist of the RAGE-DIAPH1 Signaling Axis for Diabetic Kidney Disease (DKD) Treatment
A new small molecule antagonist of the RAGE-DIAPH1 signaling axis, an important therapeutic node for the treatment of diabetes complications
Succinate Receptor 1 (SUCNR1) Antagonists to Treat Neuroinflammation
A promising therapeutic target for the prevention and/or treatment of neurodegenerative diseases.
Avobenzone-Dendrimer Conjugates
The use of a dendrimer scaffold to stabilize avobenzone in sunscreens and improve photochemical properties.
NSP14/10 Complex Inhibitors for the Treatment of SARS-CoV-2 and Pan-Coronavirus Infections
Innovative and efficacious therapeutic to treat current and future pan-coronavirus infections