Omnivore RNA Pyrophosphatase: The Key to Universal 5′-end Deprotection
A versatile enzyme capable of completely removing a wide variety of 5′ caps and oligophosphates from RNA.
Intraoperative Ultra Rapid Digital Droplet PCR to Guide Tumor Resection
Quick determination of the percentage of tumor cells and their molecular-genetic signature with a high sensitivity and specificity to guide surgical tumor resection.
Natural & Semi-Synthetic Prodrugs as Selective Antibiotics Against Colibactin-Producing E. coli for Colorectal Cancer Prevention
Precise and preventive therapeutic strategy for patients with a high risk of developing colorectal cancer.
Bright and Photostable Cyanine Dye Tags for Research Applications
Protein tags with high affinity and selectivity for off-the-shelf commercially-available fluorescent dyes that enhance their spectral properties.
Targeting mutant NT5C2 in Acute Lymphoblastic Leukemia (ALL)
Ultra High-Fidelity Single Molecule Sequencing
High-fidelity DNA sequencing method detecting base substitutions at a single-molecule level, able to explore mutation origins in cancer and aging.
CARPOOL: A High Throughput Drug Screening Platform
High throughput screening platform without the need for complex instrumentation or expensive consumables and compatible dead cell removal approach.
Selective KRAS(G12D)-Binding Monobodies for the Treatment of Cancer
A selective, efficacious and versatile treatment for KRAS(G12D)-driven cancers
SCRATCH-seq: Capturing Dynamic Genetic Changes in Lymphocytes
A platform that allows the combined profiling of chromatin accessibility, transcription analysis with parallel analysis of B and T lymphocytes antigen repertoire.
Selective NRAS-Binding Monobodies for the Treatment of Cancer
A selective and efficacious inhibitor of NRAS applicable to all NRAS-driven cancers.
miRNA-Mediated Transgene Expression System for Improved Gene Therapies and Research Reagent Applications
A highly specific and tailorable transgene expression systems compatible with conventional gene therapy platforms
Aryl-Diazonium Analogues as Potent DNA Cleavage Agents for Treating Cancer and Bacterial Infections
Potent, specific, modular, cost-effective, and synthetically-accessible agents for cytotoxic DNA cleavage.
Transcription-Associated Cas9 Targeting in Eukaryotic Cells
A novel mechanism for conditional spatiotemporal control of Cas9 activity without modification of its core protein domains, gRNA components, or expression levels.
Chip-based Prognostic Tool for Improved Leukemia Treatment Outcomes
Accurate, inexpensive, and rapid predictive tool to assess patient responsiveness to immunotherapies, such as chimeric antigen receptor (CAR) T-cell therapy
High-Throughput Design and Engineering of Mammalian Cells
A novel approach for designing, building, and delivering large DNA vectors (>100kb) for highly customizable expression of multiple gene products.
Efficient and High-Throughput Tool to Engineer Aligned 3D Collagen Matrices for Tissue Culture
IL-17 Receptor Modulator Screen
Identification of Zinc Fingers and Their DNA Targets
Novel Method for Labeling Cells and Living Animals with Isotopically Label Gases
PHOTACS: Photo-Activatable PROTACS
Spatial and temporal control over protein target degradation in diseased tissue
Multivalent Steroid Conjugates for Treatment of Castration-Resistant Prostate Cancer (CRPC)
A new generation of therapeutics for treating patients with enzalutamide-resistant CRPC.
KaryoCreate (Karyotype CRISPR Engineered Aneuploidy Technology)
Efficient and less laborious isogenic model system to study aneuploidy in cancer and congenital syndromes.
Photoactivatable Lipid Nanoparticles for Drug Delivery
Novel photoactivatable lipid nanoparticles for drug delivery that allow for light-triggered drug release at the disease site