Omnivore RNA Pyrophosphatase: The Key to Universal 5′-end Deprotection
A versatile enzyme capable of completely removing a wide variety of 5′ caps and oligophosphates from RNA.
Enhancing Neuronal Resistance to Neurodegeneration
Novel therapeutic approach to reverse or prevent the progression of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
Genetically Engineered Mice for Heavy Chain Only Antibodies (HCAbs) Production
A novel approach to produce diverse, high-affinity heavy chain only antibodies (HCAbs) in genetically engineered mice.
Intraoperative Ultra Rapid Digital Droplet PCR to Guide Tumor Resection
Quick determination of the percentage of tumor cells and their molecular-genetic signature with a high sensitivity and specificity to guide surgical tumor resection.
A Biomarker for Cerebral Amyloid Angiopathy (CAA) and Amyloid Related Imaging Abnormality Risk
A biofluid biomarker to reliably diagnose Cerebral Amyloid Angiopathy (CAA) and predict the risk of Amyloid-Related Imaging Abnormalities (ARIA) in Alzheimer’s disease patients.
Optimized Retron Editors for Enhanced Genome Engineering in Mammalian Cells
Efficient and scalable method for complex genome editing in mammalian cells that are compatible with lentiviral delivery.
Inherited Genomic Signature Testing for Improved Immune-Checkpoint Inhibition Cancer Therapies
A robust, non-invasive predictive biomarker for personalized selection of cancer treatment options involving immune-checkpoint inhibition (ICI) therapies.
Modulating Neuron and Oligodendrocyte Survival by Targeting Astrocyte-Secreted Neurotoxic Lipids and Lipoproteins
Small Molecule Inhibitors of Bacterial CSE for Treatment of Diverse Antibiotic-Resistant Infections
Innovative approache to combat antibiotic resistance and enhance the efficacy of existing antibiotics, particularly against biofilm-encased and persister bacteria
Monoclonal Antibodies for Efficient Removal of Uremic Toxins in Chronic Kidney Disease Patients
Effective removal of pathological albumin-bound uremic toxins in Chronic Kidney Disease patients, which are not removed by standard hemodialysis.
Targeting mutant NT5C2 in Acute Lymphoblastic Leukemia (ALL)
Ultra High-Fidelity Single Molecule Sequencing
High-fidelity DNA sequencing method detecting base substitutions at a single-molecule level, able to explore mutation origins in cancer and aging.
S-allylcysteine for Use in the Prevention and Treatment of Plasma Cell Dyscrasias
A treatment strategy for prevention of progression of SMM/MGUS to MM without the serious side effects of painful peripheral neuropathy.
SCRATCH-seq: Capturing Dynamic Genetic Changes in Lymphocytes
A platform that allows the combined profiling of chromatin accessibility, transcription analysis with parallel analysis of B and T lymphocytes antigen repertoire.
Epitranscriptomic Modulation of Type I IFN Pathway to Treat Cancer and Autoimmune, Inflammatory, and Infectious Diseases
An innovative and targeted approache to treat cancer and autoimmune, inflammatory, and infectious diseases
Clinical Prognostic Models for Stage II Melanoma Using Tumor miRNA Signatures
Transcription-Associated Cas9 Targeting in Eukaryotic Cells
A novel mechanism for conditional spatiotemporal control of Cas9 activity without modification of its core protein domains, gRNA components, or expression levels.
Hydrophobically Interspaced, Charged Peptides for the Treatment and Prevention of Dementia
An Innovative and efficacious therapeutic strategy to prevent and/or treat AD and other dementias.
High-Throughput Design and Engineering of Mammalian Cells
A novel approach for designing, building, and delivering large DNA vectors (>100kb) for highly customizable expression of multiple gene products.
Methods of Sensitizing Estrogen Receptor-Positive Breast Cancer to Endocrine Therapy
Treatment of Melanoma Brain Metastasis by Inhibition of Amyloid Precursor Protein Cleavage
Method of Treating Lung Cancer in Patients with LKB1 Genetically-Inactivated Tumors
Novel Targets for Cancer Therapy
Aft7ip and Setdb1 identified as novel anti-cancer therapeutic targets
Identification of Zinc Fingers and Their DNA Targets
Novel Method for Labeling Cells and Living Animals with Isotopically Label Gases
Tau Kinase Inhibitor for Preventing or Treating Glucocorticoid-Induced Osteoporosis
Novel Enzyme in CoQ10 Biosynthesis Pathway as a Novel Target to Treat Pancreatic Ductal Adenocarcinoma
Treatment for Alzheimer’s Disease by Inhibiting Formation of Platelet Micro-Clots
Antibody-Based Inhibitors of the Staphylococcus aureus Multidrug Efflux Pump NorA
Innovative and efficacious therapeutics to treat drug-resistant S. aureus infections.
Osteoarthritis (OA) Biomarker Suitable as a Point-of-Care Diagnostic
Methods of Treating Cancers Having a Deregulated Metabolic Pathway
A Novel Small Molecule PABA Derivative C45-NA Enhances Anti-Tumor Activity
Therapeutic Targeting of KMT2D Mutant Lung Cancer Via RTK-RAS Signaling Inhibition
KaryoCreate (Karyotype CRISPR Engineered Aneuploidy Technology)
Efficient and less laborious isogenic model system to study aneuploidy in cancer and congenital syndromes.
Novel Lumican-Binding Peptides Acting on the Toll-Like Receptor Pathway in Inflammation and Related Conditions
Novel peptides for treating conditions or diseases resulting from dysregulation in the immune system, such as septic shock, wound healing and autoimmune diseases.
Targeting RNA Viruses Using Inhibitors of METTL3
New and effective treatments for COVID-19 and other viral infections caused by RNA viruses.
Novel Enzyme in CoQ10 Biosynthesis Pathway as a Novel Target to Treat Neurological Diseases
Novel Biomarkers for Detection and Treatment of Immune Deficiencies During Pregnancy
A non-invasive method of detecting immune abnormalities during pregnancy to identify women at risk of infection-induced preterm birth.
Novel Wound Healing Hydrogels
Relatively cheap and easy-to-produce fibers help stabilize this novel class of wound healing hydrogel and increase efficacy.
Non-Antibiotic Treatment of Staphylococcal Infections
Using re-engineered genetic elements of bacteria as antibacterial drones to block bacterial genes involved in virulence/viability.
A Method for Treating Autoimmune Disease Exacerbated by Host Immune Response to Commensal Bacteria
Targeting disease-associated bacteria via small molecule or biologics approaches to reduce or eliminate the harmful species.
Single-Domain Antibodies (sdAbs) Against Tau and A-syn as Therapeutic and Diagnostic Tools for Neurodegenerative Diseases
The unique structural and biological features of the sdAbs provide a highly effective way of treating Alzheimer’s and Parkinson’s diseases
Novel MicroRNA-30c Analogs to Reduce Secretion of Apolipoprotein B in Human Hepatoma Cells
Therapeutic agents for lowering plasma lipid levels without causing the steatosis associated to microsomal transfer protein inhibitors.