Next-Generation Trachea-Esophageal Organoids for Scalable Disease Modeling
A scalable, reproducible, and human-specific platform for modeling trachea-esophageal development and congenital malformations such as Esophageal Atresia (EA)/ Tracheoesophageal Fistula (TEF).
First-in-Class Vaccine Platform to Halt Prion Transmission Across Species
A first-in-class vaccine approach to prevent or delay fatal, transmissible prion diseases in humans and animals.
Inhibiting Platelet Micro-Clots to Treat Alzheimer’s Disease (AD) and Cerebral Amyloid Angiopathy
An effective therapeutic that targets the vascular contributions to Alzheimer’s disease (AD), particularly cerebral amyloid angiopathy (CAA), which affects nearly all AD patients and accelerates neurodegeneration.
Rapid Generation of Single-Chain Antibodies for Use as Chimeric Antigen Receptors (CARs)
Rapid and efficient identification of high-affinity, antigen-specific single-chain antibodies for the construction of chimeric antigen receptors (CARs) to improve the effectiveness of CAR T-cell therapies, particularly in targeting challenging cancer antigens.
iCADD: Next-generation Screening Platform for Identifying Small Molecular Glue Degraders
An efficient, high-throughput platform to rapidly identify protein degraders targeting undruggable proteins for therapeutic development.
Novel Screening Platform to Identify Confirmation-Specific SHP2 Inhibitors
A novel screening platform to discover inhibitors targeting signaling active form ("on") conformation to overcome drug resistance in RAS-driven cancers and genetic disorders.